Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis

Cornea
M Teresa MagoneDavid G Hwang

Abstract

To report a case of peripheral interstitial keratitis in a patient with mastocytosis. Clinical case description and immunohistologic examination of biopsied ocular tissue. A 22-year-old woman with biopsy-proven urticaria pigmentosa, a subset of mastocytosis, presented with an active peripheral interstitial keratitis with vascularization associated with foreign body sensation and itching. Biomicroscopy of the cornea showed deep corneal inflammatory infiltrates and midstromal vascularization adjacent to a region of superior bulbar conjunctiva, which was mildly chemotic and inflamed. Topical mast cell stabilizers and a short course of topical steroids produced dramatic resolution of the lesion. Biopsy of the erythematous conjunctiva adjacent to the area of corneal inflammation showed the presence of mast cells. This is the first case of corneal inflammatory infiltration in a patient with mastocytosis. Therapy for this condition consists of a combination of topical mast cell stabilizers, topical steroids, and systemic antihistaminic therapy.

References

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Jun 1, 1996·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·R L LesserS L Sugin
Dec 26, 2001·Archives of Ophthalmology·L FineE T Cunningham
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Citations

Dec 10, 2014·Journal of Pediatric Ophthalmology and Strabismus·Alina DjougarianBrian Marr
Jan 25, 2008·Optometry : Journal of the American Optometric Association·Elliott H Myrowitz
Oct 27, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Arnaud PayerolsFrédéric Mura

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