Peripheral lymphocytes analyses in children with chronic hepatitis C virus infection

European Journal of Clinical Investigation
Asmaa NafadyNagla H Abu Faddan

Abstract

Hepatitis C virus (HCV)-specific immune response is believed to play a crucial role in viral clearance. There is, nevertheless, no reliable parameter to monitor this immune response or predict chronic HCV infection development. An observational case-control study was performed to identify such parameters, peripheral blood mononuclear cells from 57 children with chronic HCV were systemically phenotyped, and the serum level of Interferon gamma and interleukin (IL) -17 was measured. The data were compared with 37 age-matched healthy volunteers (controls). Children with chronic HCV infection had a lower frequency of natural killer cells (NK) cells, CD56Dim NK cells and expansion of CD56Bright NK cells compared with controls (P = 0.001, P < 0.0001 and P < 0.0001 respectively). Increased CD56Dim NK cells were negatively correlated with the higher viral load, R2  = 0.29, P = 0.05, while, increased NK T cells were positively correlated with high viral load, R2  = 0.17, P = 0.011. T helper cells, naive T cells, CD127 negative T cells, and HLA-DR-positive T cells significantly increased in patients than in controls. The frequency of CD4+CD25high+ T regulatory (Treg) cells increased in HCV-infected patients, compared with those in control...Continue Reading

References

Feb 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L TsaiG C Kuo
Jun 1, 1997·Journal of Leukocyte Biology·H Jaeschke, C W Smith
Oct 27, 1997·Clinical and Experimental Immunology·J CoradoJ B De Sanctis
Dec 3, 1998·Gastroenterology·M GuidoF Bortolotti
Jun 8, 1999·Annual Review of Immunology·C A BironT P Salazar-Mather
Nov 8, 2001·Trends in Immunology·M A CooperM A Caligiuri
Jan 10, 2002·The Journal of Experimental Medicine·Stefania CrottaNicholas M Valiante
Jun 6, 2002·Immunology·Kajsa WingElisabeth Suri-Payer
Mar 11, 2003·Critical Care Medicine·Jeffrey P Burns
Mar 27, 2003·Nature Reviews. Immunology·Kathryn J Wood, Shimon Sakaguchi
Nov 25, 2003·European Journal of Immunology·Miriam T BradyKingston H G Mills
Jul 24, 2004·Clinical and Experimental Immunology·A W LinA H Talal
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roniel CabreraDavid R Nelson
Mar 2, 2005·Nature Reviews. Immunology·Barbara Rehermann, Michelina Nascimbeni
Jul 9, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Charles C CaldwellAlex B Lentsch
Aug 19, 2005·Nature·David G Bowen, Christopher M Walker
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melanie A KleinschekGottfried Alber
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chihiro MorishimaDavid R Gretch
Oct 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hayley G EvansGraham M Lord
Jan 9, 2010·European Journal of Clinical Investigation·I SimeraD G Altman
Feb 9, 2010·Biochemical and Biophysical Research Communications·Omar DessoukiSeiji Okada
Aug 25, 2012·Nature Reviews. Immunology·Andrew J PrendergastPhilip J R Goulder
Jul 24, 2015·Expert Review of Anti-infective Therapy·Giuseppe IndolfiMassimo Resti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.