Peripheral mechanisms contribute to comorbid visceral hypersensitivity induced by preexisting orofacial pain and stress in female rats.

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Yaping JiRichard J Traub

Abstract

Stress exacerbates many chronic pain syndromes including irritable bowel syndrome (IBS). Among these patient populations, many suffer from comorbid or chronic overlapping pain conditions and are predominantly female. Nevertheless, basic studies investigating chronic psychological stress-induced changes in pain sensitivity have been mostly carried out in male rodents. Our laboratory developed a model of comorbid pain hypersensitivity (CPH) (stress in the presence of preexisting orofacial pain inducing chronic visceral pain hypersensitivity that significantly outlasts transient stress-induced pain hypersensitivity (SIH)) facilitating the study of pain associated with IBS. Since CPH and SIH are phenotypically similar until SIH resolves and CPH persists, it is unclear if underlying mechanisms are similar. In the present study, the visceromotor response (VMR) to colorectal distention was recorded in the SIH and CPH models in intact females and ovariectomized rats plus estradiol replacement (OVx + E2). Over several months, rats were determined to be susceptible or resilient to stress and the role of peripheral corticotrophin-releasing factor (CRF) underlying in the pain hypersensitivity was examined. Stress alone induced transient (3...Continue Reading

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Citations

Apr 23, 2021·The Journal of Pain : Official Journal of the American Pain Society·Dong-Yuan CaoRichard J Traub
Jun 4, 2021·Journal of Pain Research·Ting XiangDong-Yuan Cao

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Methods Mentioned

BETA
biopsies

Software Mentioned

GraphPad Prism
Spike

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