Peripheral metabolism of insulin, proinsulin, and C-peptide in the pregnant rat

The Journal of Clinical Investigation
A I KatzA H Rubenstein

Abstract

To clarify alterations in carbohydrate metabolism which occur in pregnancy, metabolic clearance rates of insulin, proinsulin, and C-peptide were measured by the constant infusion technique in term-pregnant rats and in virgin littermates. In addition, placental permeability to these peptides was evaluated by simultaneous determination of their concentration in fetal blood, amniotic fluid, and maternal arterial blood and the renal extraction and excretion of insulin and C-peptide were determined during simultaneous studies of renal hemodynamics. The metabolic clearance rate (MCR) of insulin was higher (P less than 0.005) in pregnant animals (61.5+/-1.7 ml/min per kg nonconceptus body weight) than in virgin littermates (51.5+/-2.2 ml/min per kg). Insulin disappearance from the circulation after both single injection and discontinuance of a constant infusion was also faster in gravid animals. In contrast, the MCR of proinsulin and C-peptide, and the disappearance of C-peptide from the circulation were similar in pregnant and control rats. The placenta was virtually impermeable to each of the three polypeptides since their mean levels in both fetal blood and amniotic fluid did not exceed 2.5 ng/ml and were only minimally influenced ...Continue Reading

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Citations

Sep 26, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Junchang GuanZhice Xu
Mar 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·A DornhorstI P Gray
Aug 1, 1993·Acta Paediatrica·L AparicioP A Gruppuso
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Feb 8, 2008·Hormones and Behavior·Melissa Emery Thompson, Cheryl D Knott
May 1, 1977·Metabolism: Clinical and Experimental·A E Kitabchi
Dec 1, 1990·Early Human Development·M Stangenberg, P Sasidharan
May 15, 1977·Klinische Wochenschrift·T ZilkerP Bottermann
Oct 1, 1977·The American Journal of Physiology·Y I TakahashiD S Goodman
Oct 1, 1992·The American Journal of Physiology·S WijkstraT R Koiter

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