Peripheral metabolism of thyroid hormones in vitamin A-deficient rats

Annals of Nutrition & Metabolism
P Higueret, H Garcin

Abstract

Some aspects of thyroid hormone metabolism were studied in rats on a vitamin A-deficient diet for 7-8 weeks. It was shown that, in deficiency, thyroxinemia, the extrathyroidal thyroxine (T4) pool and the T4 biological half-life were increased, and the T4 distribution space and the T4 disposal rate were similar to those in control rats. The in vitro formation of triiodothyronine (T3) from T4 by liver microsomes was slightly decreased under basal conditions but similar after addition of glutathione. So the increased T4 half-life in deficient animals may be related to a decreased 5'-monodeiodase activity resulting from decreased glutathione availability. In deficient rats, the T3 serum level was increased, the T3 biological half-life was similar and the T3 distribution space was much decreased.

Citations

Sep 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D TaruouraD Higueret
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·T R HallG S Spencer
Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·T R HallS Harvey
Feb 9, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·T J CapernaR Vasilatos-Younken
Oct 18, 2006·Thyroid : Official Journal of the American Thyroid Association·Ralf BiebingerMichael B Zimmermann
Apr 1, 1996·The Journal of Pharmacy and Pharmacology·M T AngleyI Stupans
Nov 1, 2005·Physiology & Behavior·Dana L HelmreichDavid B Parfitt
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Michael B ZimmermannToni Torresani
Nov 27, 2019·Nature Reviews. Molecular Cell Biology·Alina PatkeSofia Axelrod
Nov 1, 1987·Archiv für Tierernährung·G RichterG Steinbach

Related Concepts

Metazoa
Microsomes, Liver
August Rats
Thyroid Hormones
Levoxyl
Cytomel
Vitamin A Deficiency
Rats, Laboratory

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