PMID: 8964194Feb 1, 1996Paper

Peripheral microvascular disease in diabetes

Diabetes Research and Clinical Practice
J E Tooke

Abstract

In recent years a variety of techniques have been developed for studying peripheral microvascular function in man, which have provided important information regarding the functional breakdown of the microcirculation in diabetes mellitus. In insulin dependent diabetes a sequence of physiological changes have been described which support the so-called haemodynamic hypothesis: control-dependent increases in capillary pressure result in microvascular sclerosis leading to limitation of hyperaemia and loss of autoregulation. Furthermore, capillary pressure appears to be especially raised in patients with incipient nephropathy who are at particular risk of microangiopathy. The limitation of maximum hyperaemia is duration related, may be observed in early childhood, and is correlated with the degree of basement membrane thickening. In contrast in normotensive non-insulin dependent patients a different array of functional disturbances are described: Capillary pressure and capillary filtration coefficient are normal whereas maximum hyperaemia is profoundly depressed even at diagnosis. This differential pattern of abnormalities arguably reflects the impact of a prediabetic insulin resistant phase on the subsequent expression of microangio...Continue Reading

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Citations

Jul 27, 2001·Diabetes Technology & Therapeutics·A I VinikK B Stansberry
Jul 28, 2001·Diabetes Technology & Therapeutics·S I Yum, J Roe
Jul 28, 2013·Microvascular Research·Gladys Lai-Ying CheingYongping Zheng
Oct 7, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Thomas ForstAndreas Pfützner
Mar 26, 2016·Alcoholism, Clinical and Experimental Research·Srikar MunukutlaSuresh S Palaniyandi
Jan 28, 2006·Microvascular Research·Sheri R ColbergAaron I Vinik
Aug 23, 2005·Journal of Diabetes and Its Complications·Sheri R ColbergAaron I Vinik
Dec 17, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D T Ubbink, M J Jacobs
Jul 27, 2001·Diabetes Care·A I VinikG L Pittenger
Dec 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Mirela PascariuLucian Ghitescu

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