Peripheral mononuclear cell resistin mRNA expression is increased in type 2 diabetic women.

Mediators of Inflammation
Panayoula C TsiotraSotirios A Raptis

Abstract

Resistin has been shown to cause insulin resistance and to impair glucose tolerance in rodents, but in humans its physiological role still remains elusive. The aim of this study was to examine whether resistin mRNA expression in human peripheral mononuclear cells (PBMCs) and its corresponding plasma levels are altered in type 2 diabetes. Resistin mRNA levels were easily detectable in human PBMC, and found to be higher in DM2 compared to healthy women (P = .05). Similarly, mononuclear mRNA levels of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-6 were all significantly higher in DM2 compared to control women (P < .001). The corresponding plasma resistin levels were slightly, but not significantly, increased in DM2 women (P = .051), and overall, they correlated significantly with BMI (r = 0.406, P = .010) and waist circumference (r = 0.516, P = .003), but not with fasting insulin levels or HOMA-IR. Resistin mRNA expression is increased in PBMC from DM2 women, together with increased expression of the inflammatory cytokines IL-1beta, TNF-alpha, and IL-6, independent of obesity. These results suggest that resistin and cytokines might contribute to the low-grade inflammation and the increased atherogenic risk observed in...Continue Reading

References

Feb 24, 2001·Nature·C M SteppanM A Lazar
Jan 12, 2002·Obesity Research·Jürgen JankeArya M Sharma
Dec 31, 2002·Biochemical and Biophysical Research Communications·Lisa PatelStephen A Smith
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Mikako Degawa-YamauchiRobert V Considine
Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Feb 21, 2004·Science·Ronadip R BanerjeeMitchell A Lazar
Mar 17, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M BajajR A DeFronzo
Dec 4, 2004·PLoS Medicine·Michael LehrkeMitchell A Lazar
Feb 16, 2005·Circulation·Muredach P ReillyDaniel J Rader
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria BokarewaAndrej Tarkowski
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Anne BouloumiéRudi Busse
Jul 26, 2005·Biochemical and Biophysical Research Communications·Nirupama SilswalNasreen Z Ehtesham
Oct 27, 2005·The Journal of Clinical Endocrinology and Metabolism·Mary Susan BurnettBarbara V Howard
Nov 8, 2005·Cardiovascular Research·Hye Seung JungKyong Soo Park
Mar 15, 2006·Diabetologia·C Rae, A Graham
Apr 6, 2006·World Journal of Gastroenterology : WJG·Hui-Ling LuHan-Hua Lin
Aug 15, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·R Cancello, K Clément
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Mar 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Paul D AndersonMuredach P Reilly
Apr 21, 2007·Metabolism: Clinical and Experimental·Yoshiharu TokuyamaAzuma Kanatsuka
May 24, 2007·The Journal of Clinical Endocrinology and Metabolism·Véronique BeauloyeSonia M Brichard
Jun 21, 2007·American Journal of Physiology. Endocrinology and Metabolism·E MauryS M Brichard
Oct 24, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P C TsiotraS A Raptis

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Citations

Dec 25, 2010·Surgical Endoscopy·Claire EdwardsFredrick Brody
Dec 16, 2011·Veterinary Immunology and Immunopathology·Todd C HolbrookDianne McFarlane
May 7, 2011·British Journal of Pharmacology·Md S JamaluddinChangyi Chen
Mar 14, 2013·BioMed Research International·Panayoula C TsiotraSotirios A Raptis
May 12, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jing ZhangLiangzhi Xu
May 7, 2015·Journal of Diabetes and Metabolic Disorders·Mohammad Ali Takhshid, Zinab Zare
Mar 7, 2018·Inflammopharmacology·Mohamad Akbari, Vahideh Hassan-Zadeh
Sep 25, 2017·Cardiovascular Therapeutics·Elizandra Silva GuimarãesRosario Dominguez Crespo Hirata
Jan 10, 2014·Diabetes & Metabolism Journal·Hyeong Kyu Park, Rexford S Ahima
Mar 3, 2018·The Journal of Sports Medicine and Physical Fitness·Christian Cobbold
Sep 10, 2015·Hormone Molecular Biology and Clinical Investigation·Emilio Herrera, Gernot Desoye
Aug 18, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Madhukar SaxenaS Manohrdas
Mar 12, 2020·Frontiers in Cardiovascular Medicine·Alan Chait, Laura J den Hartigh
Jul 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Bàrbara ReynésAndreu Palou

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assays

Software Mentioned

SPSS
OLIGO
LightCycler Relative Quantification
Image Analyser VDS

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