PMID: 9646091Jul 1, 1998Paper

Peripheral multifocal chorioretinitis with panuveitis: clinical and immunogenetic characterization in older patients

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
B NölleE Westphal

Abstract

The etiology of peripheral multifocal chorioretinitis with panuveitis (MCP) is unclear. Characteristic signs of MCP are punched-out, white chorioretinal lesions of the lower fundus periphery, chronic smoldering chorioretinal inflammation, vitritis, and mild inflammation of the anterior chamber. In this retrospective study we investigated clinical and immunogenetic abnormalities in MCP in older patients. 20 patients (18 women, 2 men), median age 70.5 years, were investigated clinically by ophthalmologists and were typed for HLA class I antigens using the standard microlymphocytotoxicity test. Typing for HLA-DR antigens was performed by polymerase chain reaction with sequence-specific primers (PCR-SSP). The HLA controls consisted of healthy people (108 for HLA class I, 114 for HLA class II). MCP was bilateral in 18 patients. Disease-related symptoms were present for 8 months (median) before diagnosis. The main presenting symptoms or findings were glaucoma (in 11 patients), visual loss (7), iritis (5), and vitritis (2). Anterior segment changes were frequently seen: keratitic precipitates (32 eyes), anterior chamber cells (25 eyes), aqueous flare (26 eyes), posterior synechiae (22 eyes), secondary glaucoma (15 eyes), and iris neov...Continue Reading

Citations

Dec 12, 2001·Survey of Ophthalmology·S R BoydS Lightman
Feb 5, 2002·Ophthalmology·Shawkat Shafik MichelC Stephen Foster
Aug 7, 2012·Acta Ophthalmologica·Annemarie KoopAniki Rothova
Jan 18, 2015·American Journal of Ophthalmology·Jeannette Ossewaarde-van NorelAniki Rothova
Apr 1, 2008·Retinal Cases & Brief Reports·Jonathan P LevineLawrence A Yannuzzi
Mar 3, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Joanna Brydak-GodowskaDariusz Kęcik

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