Jul 1, 1977

Peripheral nerve abnormality in multiple sclerosis

Annals of Neurology
M PollockS Allpress

Abstract

Biopsy specimens of sural nerve from 10 patients with multiple sclerosis (MS), of whom only 1 was severely disabled, were assessed by morphometric techniques and compared to nerves from age-matched controls. The frequency of abnormal teased fibers was increased in MS nerve, with many internodes showing at least a 50% reduction in myelin thickness. Myelinated nerve fiber densities were not significantly different in MS and control nerves. Regression analysis of axonal area on number of myelin lamellae indicated a generalized reduction of myelin lamellae in this disorder. It is suggested that peripheral myelin may be involved in multiple sclerosis.

  • References13
  • Citations60

Citations

Mentioned in this Paper

Structure of Sural Nerve
Myelin
Schwann Cells
Axon
Perineurium
Peripheral Neuropathy
Multiple Sclerosis, Acute Fulminating
Multiple Sclerosis

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