PMID: 8585683Oct 1, 1995Paper

Peripheral nerve allograft transplantation with FK506: functional, histological, and immunological results before and after discontinuation of immunosuppression

Annals of Plastic Surgery
R BüttemeyerN F Jones

Abstract

Two-centimeter nerve allografts were transplanted across a major histocompatibility barrier from donor ACI rats into a 0.5-cm gap in the sciatic nerve of recipient Lewis rats and immunosuppressed with FK506, 2 mg/kg per day for 3 months. One group of animals continued to receive intermittent immunosuppression with FK506, 2 mg/kg twice a week for another 2 months, whereas the second group of animals received no further immunosuppression in order to determine whether rejection of nerve allografts can still occur after immunosuppression is withdrawn, even after the axons have regenerated through the nerve graft. The sciatic function index improved from -76.3 at 3 months to -46.6 at 5 months in those animals continuing to receive intermittent immunosuppression, but only improved to -66.8 at 5 months when immunosuppression was discontinued. Similarly, somatosensory evoked potentials demonstrated an improvement in relative latency from 2.3 msec at 3 months to 0.34 msec at 5 months in animals continuing to receive intermittent immunosuppression, but only improved to 1.29 msec at 5 months when immunosuppression was discontinued. Nerve allografts continuing to receive intermittent immunosuppression showed no signs of rejection by light ...Continue Reading

Citations

Mar 7, 2000·Microsurgery·M SiemionowG Lister
Jun 8, 1999·Plastic and Reconstructive Surgery·V B Doolabh, S E Mackinnon
Jun 14, 2000·Plastic and Reconstructive Surgery·H P LorenzM T Longaker
Jun 5, 2002·Plastic and Reconstructive Surgery·Terence M MyckatynSusan E Mackinnon
Sep 10, 2013·Journal of Biomedical Science·Cheng-Shyuan RauChing-Hua Hsieh
Oct 19, 2006·Journal of Neurosurgery·Cristina AubáOscar Gorría
Nov 16, 2011·The Journal of Hand Surgery, European Volume·D Q D Phan, F Schuind
Apr 6, 1999·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·H FansaW Schneider
Apr 20, 2004·The Laryngoscope·Michael J BrennerSusan E Mackinnon
Aug 26, 2011·Microsurgery·Vivian M YuMichael J Brenner
Jul 29, 2006·Plastic and Reconstructive Surgery·Alison K SnyderSusan E Mackinnon
Aug 26, 2006·Plastic and Reconstructive Surgery·Bradford L CottrellClaudio Maldonado
Mar 24, 2005·Annals of Plastic Surgery·John N JensenSusan E Mackinnon
Apr 3, 2008·Microsurgery·Michael J BrennerSusan E Mackinnon

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