Peripheral nerve blocks with sedation using propofol and alfentanil target-controlled infusion for hip fracture surgery: a review of 6 years in use

Journal of Clinical Anesthesia
D F JohnstonK Dane

Abstract

Over the last 6 years, our center has introduced a novel technique combining peripheral nerve blocks (femoral and lateral femoral cutaneous nerves) with sedation using propofol with alfentanil target-controlled infusion for hip fracture surgery. The purpose of this review was to identify if adverse outcomes (of mortality and length of stay) were associated with its introduction compared to spinal or general anesthesia. Retrospective data collection from hospital fracture database. Data were analyzed using Cox regression (adjusted for age, sex, and American Society of Anesthesiologists grade) to compare survival and length of stay data across the different anesthetic techniques used for hip fracture surgery. This technique was used in 472 (20%) of 2360 hip fractures. There was no significant difference between peripheral nerve blocks with propofol/alfentanil sedation/analgesia for mortality up to 120days (hazard ratio, 0.76; 95% confidence interval, 0.54-1.06; P=.11) and length of stay (hazard ratio, 1.03; 95% confidence interval, 0.91-1.17; P=.63) when compared to the other anesthetic techniques of spinal and general anesthesia. This novel technique does not appear to be associated with adverse mortality or length of stay after...Continue Reading

Associated Clinical Trials

Jul 2, 2019·Dr.med.Ronald Seidel, Dr.med.Ronald Seidel

References

Aug 1, 1992·British Journal of Anaesthesia·I N TaylorJ B Glen
Jan 1, 1991·Anesthesiology·S L Shafer, J R Varvel
Apr 27, 1999·Anaesthesia·T EngelhardtD R Ball
Jan 12, 2000·Scottish Medical Journal·R E Dickson, R E Patey
Oct 11, 2002·Archives of Internal Medicine·Valerie A LawrenceJeffrey L Carson
Jun 22, 2005·Best Practice & Research. Clinical Anaesthesiology·Andrea Casati, Marta Putzu
Mar 24, 2006·BMJ : British Medical Journal·Alex Bottle, Paul Aylin
Jan 30, 2007·The Journal of Bone and Joint Surgery. British Volume·N Von MeibomB Davis

❮ Previous
Next ❯

Citations

Oct 11, 2017·Anesthesia and Analgesia·Joanne GuaySandra L Kopp
May 12, 2017·The Cochrane Database of Systematic Reviews·Joanne GuaySandra Kopp
Oct 12, 2019·Anesthesia, Essays and Researches·Maha Ahmed Abo-ZeidSameh Hany Emile
Feb 6, 2018·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Joseph J RuzbarskyVitaly Kotlyar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.