Peripheral nerve elongation by laser Doppler flowmetry-monitored expansion: an experimental basis for future application in the management of peripheral nerve defects

Plastic and Reconstructive Surgery
L P van der WeyF J Gabreëls

Abstract

Nerve grafting often fails to achieve optimal functional results and is always associated with donor-site morbidity. Peripheral nerve elongation by the use of a tissue expander may provide a useful adjunct in the management of segmental nerve loss. In the present study, rabbit sciatic nerve (n = 40) was elongated by expansion while nerve blood flow was monitored by laser Doppler flowmetry. Elongation was possible up to 40 percent with preservation of clinical nerve function. Nerve conduction velocity of the expanded nerves decreased in a linear relation to elongation. The reduction in nerve conduction velocity may be secondary to the observed widening of the nodes of Ranvier and altered membrane properties after remyelination. Demyelination and remyelination of whole internodes and axonal degeneration occurred only sporadically. Thus laser Doppler flowmetry-monitored expansion provides a safe method for elongation of intact rabbit sciatic nerve while nerve function and axonal continuity are preserved. Further studies are needed before clinical use is considered. This technique may represent a favorable alternative to nerve grafting for the treatment of peripheral nerve defects.

References

Dec 1, 1978·Annals of Neurology·J K KorthalsH M Wisniewski
Jul 1, 1976·The Journal of Hand Surgery·J K TerzisR W Hakstian
Sep 1, 1992·Plastic and Reconstructive Surgery·B E Cohen, A Ruiz-Razura
Jul 1, 1992·Journal of Reconstructive Microsurgery·C M BaroneA Frempog-Bodeau
Feb 1, 1992·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·R H Milner, P R Wilkins
Oct 1, 1991·Muscle & Nerve·M R Swenson, L Cornacchia
Mar 1, 1990·Plastic and Reconstructive Surgery·S E Mackinnon, A L Dellon
Nov 1, 1990·World Journal of Surgery·H Millesi
Jul 1, 1989·British Journal of Plastic Surgery·R H Milner
Feb 1, 1986·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·K Ogata, M Naito
Aug 1, 1973·Journal of the Neurological Sciences·J Ochoa, L Marotte
Nov 1, 1980·Journal of the Neurological Sciences·K J Smith, S M Hall
Oct 1, 1984·Plastic and Reconstructive Surgery·C Radovan
Oct 1, 1984·British Journal of Plastic Surgery·L C Argenta
Apr 1, 1982·Journal of the Neurological Sciences·K J SmithS M Hall
Jul 1, 1993·Journal of the Neurological Sciences·L P van der WeyP H Spauwen

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Citations

Nov 26, 2003·Experimental Neurology·Yuki HaraNaoyuki Ochiai
Oct 16, 2014·Neural Regeneration Research·Kenneth M VazSameer B Shah
Jun 2, 2011·Microsurgery·Paulo Roberto KecheleTânia Silvia Fröde
Dec 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yuki HaraNaoyuki Ochiai
Jun 15, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yuki HaraHajime Mishima
Dec 10, 2009·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Yasutaka YamadaNaoyuki Ochiai

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