Peripheral Nerve Injury-Induced Astrocyte Activation in Spinal Ventral Horn Contributes to Nerve Regeneration

Neural Plasticity
Changhui QianJiasong Guo

Abstract

Accumulating evidences suggest that peripheral nerve injury (PNI) may initiate astrocytic responses in the central nervous system (CNS). However, the response of astrocytes in the spinal ventral horn and its potential role in nerve regeneration after PNI remain unclear. Herein, we firstly illustrated that astrocytes in the spinal ventral horn were dramatically activated in the early stage following sciatic nerve injury, and these profiles were eliminated in the chronic stage. Additionally, we found that the expression of neurotrophins, including brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin-3 (NT-3), also accompanied with astrocyte activation. In comparison with the irreversible transected subjects, astrocyte activation and the neurotrophic upregulation in the early stage were more drastic in case the transected nerve was rebridged immediately after injury. Furthermore, administering fluorocitrate to inhibit astrocyte activation resulted in decreased neurotrophin expression in the spinal ventral horn and delayed axonal regeneration in the nerve as well as motor function recovery. Overall, the present study indicates that peripheral nerve injury can initiate astrocyte activation accompanie...Continue Reading

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Citations

Apr 6, 2019·Frontiers in Cellular Neuroscience·Lixia LiJiasong Guo
Feb 15, 2019·International Journal of Molecular Sciences·Zhiwen ZhouRyuta Koyama
Dec 4, 2020·Neural Regeneration Research·Lixia LiJiasong Guo
Jan 30, 2021·Neural Regeneration Research·Zhi-Bin DingCun-Gen Ma

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