PMID: 10842232Jun 8, 2000Paper

Peripheral nerve injury leads to the establishment of a novel pattern of sympathetic fibre innervation in the rat skin

The Journal of Comparative Neurology
Isabella RuoccoAlfredo Ribeiro-da-Silva

Abstract

Peripheral nerve injury has been shown to result in sympathetic fibre sprouting around dorsal root ganglia (DRG) neurons. It has been suggested that this anomalous sympathetic fibre innervation of the DRG plays a role in neuropathic pain. Other studies have suggested an interaction between sympathetic and sensory fibres more peripherally. To date, no anatomical study of these possible interactions in the terminal fields of sensory and sympathetic fibres has been performed; therefore, the authors set out to study them in the rat lower lip after bilateral lesions of a sensory nerve, the mental nerve (MN). Immunocytochemistry for both substance P (SP) and dopamine-beta-hydroxylase (DbetaH) was performed. Within the first week post-MN lesions, the SP-immunoreactive (IR) fibres had degenerated almost completely, whereas DbetaH-IR fibres were found in the upper dermis, an area from which they normally are absent. These DbetaH-IR fibres were present in the upper dermis at all postsurgery times studied (1, 2, 3, 4, 6, and 8 weeks). It is noteworthy that, although, by week 6 post-MN lesions, SP-IR fibre reinnervation of the lower lip was occurring, the DbetaH-IR fibres still were present in the upper dermis. Quantification revealed that...Continue Reading

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Citations

Oct 19, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guohua ZhangKaren J Berkley
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael P JankowskiH Richard Koerber
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Jul 13, 2002·The Journal of Comparative Neurology·Isabella RuoccoAlfredo Ribeiro-da-Silva
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Oct 13, 2006·Progress in Neurobiology·Antti Pertovaara

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