Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia

E M McLachlanM Michaelis


In humans, trauma to a peripheral nerve may be followed by chronic pain syndromes which are only relieved by blockade of the effects of sympathetic impulse traffic. It is presumed that, after the lesion, noradrenaline released by activity of sympathetic postganglionic axons excites primary afferent neurons by activating alpha-adrenoceptors, generating signals that enter the 'pain pathways' of the central nervous system. The site of coupling is unclear. In some patients local anaesthesia of the relevant peripheral nerve does not alleviate pain, implying that ectopic impulses arise either within the central nervous system, or in proximal parts of the primary afferent neurons. In experimentally lesioned rats, activity can originate within the dorsal root ganglia. Here we report that, after sciatic nerve ligation, noradrenergic perivascular axons in rats sprout into dorsal root ganglia and form basket-like structures around large-diameter axotomized sensory neurons; sympathetic stimulation can activate such neurons repetitively. These unusual connections provide a possible origin for abnormal discharge following peripheral nerve damage. Further, in contrast to the sprouting of intact nerve terminals into nearby denervated effector ...Continue Reading


May 1, 1979·The Journal of Comparative Neurology·M DevorP D Wall
Dec 1, 1990·Journal of Neurophysiology·M Devor, P D Wall
Aug 1, 1988·Trends in Neurosciences·S Rotshenker
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J L Morris, I L Gibbins
Nov 1, 1987·The Anatomical Record·H Schmalbruch
Oct 1, 1980·Journal of Neuroscience Methods·J C De la Torre
Jan 1, 1984·Annals of Neurology·W R Kennedy, M Sakuta
Jan 1, 1981·Annual Review of Neuroscience·M C BrownW G Hopkins

❮ Previous
Next ❯


Jan 8, 1996·The Journal of Comparative Neurology·M Karlsson, C Hildebrand
Nov 1, 1994·Annals of Neurology·D F BrausJ Strobel
Nov 18, 1998·Annals of Neurology·A L OaklanderR A Meyer
Sep 20, 2001·Muscle & Nerve·J N Campbell
Oct 13, 2006·European Journal of Applied Physiology·Magda Passatore, Silvestro Roatta
Mar 20, 2008·Journal of Neural Transmission·B Jabbari
Mar 17, 2001·Current Pain and Headache Reports·B K Taylor
Sep 14, 2004·Current Pain and Headache Reports·Manuel Martinez-Lavin
Jun 1, 1994·Trends in Pharmacological Sciences·A DrayA Dickenson
Aug 1, 1994·Current Opinion in Neurobiology·C J Woolf, T P Doubell
Oct 1, 1995·Current Opinion in Neurobiology·S B McMahon, J V Priestley
Mar 11, 2004·Brain Research. Molecular Brain Research·Susan M W HarrisonHeidi S Phillips
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Linda S Sorkin, Tony L Yaksh
Nov 8, 2001·European Journal of Pharmacology·D H VrintenW H Gispen
Sep 17, 2003·Journal of Manipulative and Physiological Therapeutics·Xue-Jun SongRonald L Rupert
Jan 1, 1996·Pharmacology & Therapeutics·B J Pleuvry, G R Lauretti
Jan 1, 1997·Pharmacology & Therapeutics·B V MacFarlaneH A Benson
Dec 10, 1999·Journal of the Autonomic Nervous System·F A Abdulla, P A Smith
Apr 13, 1999·Trends in Neurosciences·M KoltzenburgS B McMahon
Nov 27, 1998·Neuroscience Research·T Kumazawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.