PMID: 8467586Jan 1, 1993Paper

Peripheral nerve lesions: the neuropharmacological outlook

Clinical Neurology and Neurosurgery
H Kerkhoff, F G Jennekens

Abstract

A review is presented of compounds with trophic effects on the peripheral nervous system. A distinction should be made between three types of effect: enhancement of neurone survival, stimulation of regeneration and induction or stimulation of collateral sprouting. On the basis of data currently available, laminin and insulin-like growth factor I are the most promising substances for regeneration of peripheral nerve lesions. Future investigations of laminin should provide an answer to the query whether local administration facilitates sprouts to cross the gap between proximal and distal nerve stumps. Further experiments are required on effects of systemic administration of IGF-I in animal models of peripheral nerve lesions before investigations can be initiated in man.

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Citations

Aug 15, 2003·Journal of Biomedical Materials Research. Part a·Shenguo WangYuqing Wan
Nov 23, 2006·Journal of Biomedical Materials Research. Part a·Suk Ho BhangByung-Soo Kim
Feb 7, 2013·Biomedical Materials·Nima Khadem MohtaramStephanie M Willerth

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