Peripheral Nerve Sheath Tumors of the Eyelid Dermis: A Clinicopathologic and Immunohistochemical Analysis

Ophthalmic Plastic and Reconstructive Surgery
Anna M Stagner, Frederick A Jakobiec

Abstract

To determine the incidences, clinical features, and detailed histopathologic and immunohistochemical findings of 10 peripheral nerve tumors (isolated neurofibromas, solitary circumscribed neuromas [SCNs], and schwannomas) localized to the eyelid dermis. In this retrospective clinicopathologic study, clinical records and paraffin sections subjected to hematoxylin and eosin, Masson trichrome, periodic acid-Schiff, reticulin, and Alcian blue staining were critically reviewed from each case. Additional paraffin sections were immunoreacted for S100, neurofilament, CD34, epithelial membrane antigen (EMA), glucose transporter-1 (glut-1), and calretinin. Ten patients with a median age of 57 years had solitary, small, flesh-colored papules, 70% at the eyelid margin. Microscopically, they were diagnosed either as a SCN or an isolated neurofibroma. SCN was diffusely S100-positive (and sometimes diffusely calretinin-positive) with myriad neurofilaments. Fascicles of cells were separated by CD34-positive septa, and the lesions were surrounded by a glut-1/EMA-positive capsule. Neurofibromas were calretinin-negative and had a moderate number of S100-positive cells, with widely scattered neurofilaments, many CD34-postive intermixed cells, and ...Continue Reading

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Citations

Dec 26, 2016·Survey of Ophthalmology·Frederick A JakobiecArthur K F Tong
Feb 22, 2017·Ophthalmic Plastic and Reconstructive Surgery·Frederick A JakobiecSuzanne K Freitag
Jul 13, 2017·Ophthalmic Plastic and Reconstructive Surgery·Frederick A JakobiecBranko Bojovic
Jan 21, 2021·Cell and Tissue Research·N Nieto-NicolauA Vilarrodona
Sep 21, 2021·Biopreservation and Biobanking·Nuria Nieto-NicolauAnna Vilarrodona

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