Peripheral Nerve Ultrasound in Small Fiber Polyneuropathy

Ultrasound in Medicine & Biology
Hamid EbadiVera Bril

Abstract

Routine nerve conduction studies are normal in patients with small fiber neuropathy (SFN), and a definitive diagnosis is based on skin biopsy revealing reduced intra-epidermal nerve fiber density (IENFD). In large fiber polyneuropathy, ultrasound (US) parameters indicate enlargement in cross-sectional area (CSA). This study was aimed at determining if similar changes in large fibers on US are apparent in patients with SFN. Twenty-five patients with SFN diagnosed by reduced IENFD and 25 age- and body mass index (BMI)-matched healthy controls underwent US studies of sural and superficial peroneal sensory nerves. The mean CSA of the sural nerve in SFN patients was 3.2 ± 0.8 mm(2), and in controls, 2.7 ± 0.6 mm(2) (p < 0.0070), and this was independent of sex. There was no difference in the thickness-to-width ratio or echogenicity of the nerves. US of the sural nerve in patients diagnosed with small fiber neuropathy reveals an enlarged cross-sectional area similar to that in large fiber polyneuropathy.

References

Jul 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G W ZackS A Latt
Jun 14, 2003·The Neurologist·Amer Al-ShekhleeDavid C Preston
Oct 24, 2006·Muscle & Nerve·Takao ItoKazutoshi Nishiyama
Jan 1, 1995·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·J C YenS Chang
May 20, 2008·Journal of Digital Imaging·Ashraf A SaadLinda G Shapiro
Jun 18, 2009·Muscle & Nerve·Michael S CartwrightJames B Caress
Aug 22, 2009·Muscle & Nerve·Craig M ZaidmanAlan Pestronk
Jan 27, 2010·Pflügers Archiv : European journal of physiology·Angelika LampertAndreas Leffler
Apr 14, 2011·Muscle & Nerve·Francis O Walker, Michael S Cartwright
May 11, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L PaduaC Martinoli
May 28, 2011·Acta Neurologica Scandinavica·Y A RajaballyA Khan
Nov 22, 2011·Muscle & Nerve·Marta LucchettaLuca Padua
Jan 6, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J Boom, L H Visser
May 1, 2013·Muscle & Nerve·Lisa D Hobson-Webb
May 18, 2013·Muscle & Nerve·Michael S Cartwright, Francis O Walker
May 25, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H S GoedeeL H Visser
Feb 25, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jae Hong JangByung-Jo Kim
Mar 19, 2014·Muscle & Nerve·Alexander GrimmHubertus Axer
Mar 25, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hiroyuki NoderaRyuji Kaji
Aug 22, 2014·Current Diabetes Reports·Giuseppe LauriaUNKNOWN PROPANE Study group
Sep 25, 2014·Journal of the Peripheral Nervous System : JPNS·Brigitte A BrouwerCatharina G Faber

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Citations

Feb 14, 2016·Muscle & Nerve·Amanda Cy Chan, Einar P Wilder-Smith
Apr 2, 2016·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Hans D KatzbergAri Breiner
Oct 17, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Adeniyi A BorireArun V Krishnan
May 31, 2017·Muscle & Nerve·Adeniyi A BorireArun V Krishnan
Dec 21, 2018·Journal of the Peripheral Nervous System : JPNS·Maurice SopacuaCatharina G Faber
May 10, 2019·BMJ : British Medical Journal·Kelly Graham Gwathmey, Kathleen T Pearson
Feb 14, 2020·Muscle & Nerve·Thomas W LycanRoy E Strowd
Nov 16, 2018·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jean K Mah, Nens van Alfen
Dec 19, 2020·Journal of Neuromuscular Diseases·Lisette R M RaasingJan C Grutters
Dec 19, 2020·Brain Sciences·Maria NolanoVincenzo Provitera
Aug 11, 2021·Muscle & Nerve·Franco GemignaniGiovanni Pavesi

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