Peripheral nervous system involvement in multiple sclerosis

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
K GartzenN Putzki

Abstract

To investigate possible peripheral nervous system (PNS) affection in patients with multiple sclerosis (MS) by standard nerve conduction velocity (SNC) and pain-related evoked potentials (PREP), a novel electrophysiological method for diagnosing small fibre neuropathy. Former neuropathological and electrophysiological studies demonstrated subtle PNS affection in MS, but routine measurements are mostly normal. Small fibre polyneuropathy is associated with several autoimmune diseases but has not been investigated in MS yet. Fifty-four patients with MS (43 relapsing-remitting, 11 secondary progressive MS) underwent SNC of the tibial, sural and peroneal nerve. Twenty-one patients additionally underwent PREP. SNC abnormalities were observed in 29.6% of all patients and 14.2% of all nerves examined No abnormalities on PREP were found. We demonstrated subtle alterations on routine electrophysiological measurements in patients with MS without hints for small fibre pathology.

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Citations

Dec 3, 2011·Der Schmerz·N HansenZ Katsarava
Sep 14, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H Schapira, M Hillbom
Aug 22, 2013·Journal of Anesthesia·Alexandros MakrisIosifina Karmaniolou
Jan 1, 2014·Multiple Sclerosis and Related Disorders·Olga KrökkiAnne M Remes
May 31, 2011·Autoimmunity Reviews·Christoph Kamm, Uwe K Zettl
Oct 13, 2017·Annals of Neurology·Johann M E JendeJennifer Kollmer
Oct 1, 2011·International Anesthesiology Clinics·Philipp LirkQuinn Hogan
Jun 1, 2020·Acta Neurologica Scandinavica·Sepehr MamoeiUlrik Dalgas
Jul 23, 2014·Current Opinion in Anaesthesiology·Julie R McSwainSylvia H Wilson
Jun 25, 2020·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Han YinKathleen Baster
Nov 26, 2020·Neurology. Neuroimmunology and Neuroinflammation·Ellen OudejansAnne-Marie van Dam

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