PMID: 6969863Sep 1, 1980Paper

Peripheral neuropathy in mouse hereditary diabetes mellitus. II. Ultrastructural correlates of degenerative and regenerative changes

Neuropathology and Applied Neurobiology
K A CarsonJ S Hanker

Abstract

The fine structural changes in some peripheral nerves and sensory ganglia from mice (C57BL/KsJ, db/db) with an hereditary diabetic syndrome, similar to human maturity-onset diabetes mellitus, were studied during development of the mild peripheral neuropathy. The abnormalities observed included axonal degeneration, disruption of myelin, accumulation of electro-dense material in axons, satellite cells and Schwann cells, increased frequency of pi granules of Reich in Schwann cells, enlarged mitochondria, and proliferated and thickened Schwann cell basal laminae. Distal hind limb nerves were most affected. Sensory ganglion neurons were normal except for occasional chromatolytic cells, so that nerve cell loss was not present in this peripheral neuropathy. Morphological indications of Schwann cell hyperplasia, hypertrophy, and axonal sprouting supported the contention that a continuous cycle of axonal degeneration and regeneration was occurring. The ultrastructural changes and accumulation of electron-opaque, lipid material suggested that a defect in lipid metabolism, secondary to the diabetic condition, could be an important factor in the peripheral neuropathy in the diabetic mouse.

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Citations

Oct 1, 1995·Diabetes/metabolism Reviews·S Yagihashi
Jan 1, 1984·Acta Neuropathologica·H C Powell, R R Myers
Nov 1, 1981·Journal of the Neurological Sciences·S A MooreB L O'Connor
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·K A CarsonN Kirshner
Nov 29, 2007·Journal of the Peripheral Nervous System : JPNS·Douglas E WrightJanelle M Ryals
Nov 1, 1983·The Journal of Surgical Research·R H Bell, R J Hye
Mar 1, 1986·Experimental Neurology·V R Ras, P B Nava
Jul 1, 1986·Diabetes Research and Clinical Practice
Oct 1, 1984·Journal of Comparative Pathology·A DianiG Gerritsen
Jul 1, 1986·Veterinary Pathology·L ForceK Scarrat
Jun 22, 2001·Journal of Child Neurology·A VerrottiF Chiarelli
Jan 10, 2008·Neuro-degenerative Diseases·B FrickerF René
Sep 1, 1982·Journal of Autonomic Pharmacology·H F WilsonD R Tomlinson
Dec 1, 1990·Diabetes/metabolism Reviews·S L Rabinowe
Sep 28, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M D CrowellB E Lacy
Jul 1, 1981·Muscle & Nerve·G Said, S Duckett

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