Peripheral neuropathy is associated with insulin resistance independent of metabolic syndrome

Diabetology & Metabolic Syndrome
Ling HanBin Lu

Abstract

To determine the association of insulin resistance, metabolic syndrome (MetS) with peripheral neuropathy (PN). This cross-sectional study consisted of 2035 subjects in Shanghai who were classified as with MetS and without MetS. The new International Diabetes Federation (IDF) criterion was used to define MetS. HOMA-IR was applied to evaluate insulin resistance. All subjects underwent complete foot examination. PN was assessed according to the neuropathy symptom and neuropathy disability scores. Binary logistic regression was performed to analyze the contributions of insulin resistance, features of MetS to PN. (1) The percentage of PN was 4.0% in our study. Patients with MetS (47.7%) had a higher percentage of PN (5.5% vs. 2.6%, respectively, P = 0.001). With the components of MetS increased (non-MetS, three, four, five), a linear increase in the proportion of peripheral neuropathy was observed (2.6%, 4.8%, 5.6% and 7.2%; respectively, P for trend = 0.001). (2) In patients with PN, the average age of patients was significantly older than the corresponding non-PN patients. Waist circumference, fasting blood glucose, HbA1c, proportion of treatment for diabetes and hypertension were significantly higher in PN group compared with non...Continue Reading

References

Nov 5, 1999·Diabetes Care·R H Lee, A L Dellon
Feb 2, 2002·Journal of Epidemiology and Biostatistics·M M ZarrelliUNKNOWN Italian General Practitioner Study Group
Jan 15, 2003·Neurology·C J SumnerM Polydefkis
Mar 11, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·L A CostaJ L Gross
Jun 12, 2004·Experimental Neurology·Q-G XuD W Zochodne
Aug 20, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·C DaousiS J Benbow
Dec 13, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Giorgio Sesti
Jan 17, 2012·Trends in Endocrinology and Metabolism : TEM·Bhumsoo Kim, Eva L Feldman
May 23, 2012·Lancet Neurology·Brian C CallaghanEva L Feldman
Dec 4, 2012·Diabetes Care·Nora A VisserNicolette C Notermans
Jun 5, 2013·Journal of Diabetes and Its Complications·A Gordon Smith, J Robinson Singleton
Jul 16, 2014·Advances in Nutrition·Tamara N Dunn, Sean H Adams

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Citations

Nov 1, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Onur AkınBülent Ünay
Feb 14, 2017·Journal of Diabetes Research·M C Perez-MatosC O Mendivil
Feb 24, 2017·Diabetology & Metabolic Syndrome·Xiaona QiaoBin Lu
Oct 4, 2017·International Journal of Dermatology·Enrique LoayzaIvan Cherrez Ojeda
Mar 27, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Qianna ZhenQian Ge
Jul 15, 2015·Journal of Diabetes and Metabolic Disorders·Ozra Tabatabaei-MalazyMohammad Abdollahi
Apr 9, 2020·Frontiers in Cellular and Infection Microbiology·Karuna E W VendrikMaria Fiorella Contarino
Jan 19, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Anna GrisoldEva L Feldman
Apr 25, 2018·Annals of Clinical and Translational Neurology·Brian C CallaghanLinong Ji
Nov 19, 2020·Pediatric Diabetes·Gulcin AkinciEva L Feldman
Mar 9, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Tushar IssarArun V Krishnan
Jul 6, 2020·Mayo Clinic Proceedings·Brian C CallaghanEva L Feldman
May 7, 2021·Annals of Clinical and Translational Neurology·Amy E RumoraEva L Feldman
May 25, 2021·JCI Insight·Evan L ReynoldsBrian C Callaghan

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