PMID: 3320571Jan 1, 1987Paper

Peripheral oestrogen metabolism in postmenopausal women with or without breast cancer: the role of dietary lipids and growth factors

Journal of Steroid Biochemistry
M J ReedV H James

Abstract

Studies we have carried out have revealed significant differences in oestrogen production and metabolism between normal women and postmenopausal women with breast cancer. The free, biologically available fraction of oestradiol is elevated in plasma from women with breast cancer and we have found that metabolic clearance rates and production rates of oestradiol are also increased. In vitro studies have suggested that lipids can influence the distribution of sex steroids in plasma and we have therefore examined the effect of dietary lipids on the distribution of sex steroids in plasma in vivo. Consumption of a meal with a high saturated fat content or the oral or i.v. administration of "Intralipid", a stabilised emulsion of soya bean oil that is high in unsaturated free fatty acids, had little effect on the available fractions of oestradiol in plasma. However, results from a preliminary study suggest that long-term changes in dietary fat intake can alter the distribution of steroids in plasma. It is concluded that dietary lipids may influence the availability of sex steroids to tissues. Such a mechanism could account for the significant correlation that has been found between dietary fat consumption and the incidence of breast ca...Continue Reading

References

Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·B Armstrong, R Doll
Feb 1, 1986·Journal of Steroid Biochemistry·M J ReedV H James
Aug 15, 1986·International Journal of Cancer. Journal International Du Cancer·J M McNeillV H James
Dec 15, 1986·International Journal of Cancer. Journal International Du Cancer·C La VecchiaS Franceschi
Dec 15, 1985·International Journal of Cancer. Journal International Du Cancer·P A BeranekV H James
Aug 1, 1967·The Journal of Clinical Endocrinology and Metabolism·C S HollanderJ H Oppenheimer
Jan 15, 1982·International Journal of Cancer. Journal International Du Cancer·J W MooreP K Siiteri
Dec 1, 1981·Journal of Steroid Biochemistry·V H JamesE J Folkerd

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Citations

Jan 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M J ReedJ K Cruickshank
Aug 1, 1992·Postgraduate Medical Journal·K T Khaw

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