Peripheral opioid analgesia in laparoscopic cholecystectomy

Regional Anesthesia and Pain Medicine
Renata ZajaczkowskaJan Dobrogowski

Abstract

Recent research has revealed that opioids can act directly on the peripheral terminals of afferent nerves to mediate antinociception. The aim of this study was to assess the influence of peripheral morphine administration on the nociception process in the postoperative period. One hundred fifty patients for laparoscopic cholecystectomy were randomly divided into 5 groups. Group M patients (n=30) received local infiltration at trocar insertion points with 2 mg morphine in 20 mL of 0.9% NaCl solution (5 mL of solution per point) 10 minutes before the operation. For group B patients (n=30), the solution used for infiltration was 20 mL of 0.25% bupivacaine; for group M+B patients (n=30), the solution was 2 mg morphine in 20 mL of 0.25% bupivacaine; and for group S patients (n=30), the solution was 20 mL 0.9% NaCl. For group S+M patients (n=30), trocar insertion points were infiltrated with 20 mL of 0.9% NaCl, and patients in this group were given 2 mg of subcutaneous morphine 10 minutes before the surgery. Postoperative analgesic therapy was provided by on-demand analgesia with tramadol. After surgery, the following were measured: pain intensity scored on the visual analog scale, total tramadol requirement, time from the end of the...Continue Reading

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Citations

Apr 1, 2014·The Cochrane Database of Systematic Reviews·Kurinchi Selvan GurusamyBrian R Davidson
Mar 13, 2014·The Cochrane Database of Systematic Reviews·Sofronis LoizidesBrian R Davidson
Jun 1, 2020·Regional Anesthesia and Pain Medicine·Johnny Wei BaiVincent Chan
Sep 4, 2020·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Mitra EftekhariyazdiRoghayeh Zardosht

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