[Peripheral opioid receptors and their role in postoperative pain management.].

Der Schmerz
C Stein

Abstract

Animal experiments have unequivocally demonstrated peripheral antinociceptive effects of opioids in inflamed tissue. Exogenous mu-, delta- und kappa-agonists can produce such effects. Opioid receptors are present on peripheral terminals of primary afferent neurons and their endogenous ligands are produced and contained in resident immune cells within the inflamed tissue. These endogenous opioid peptides can apparently be released during stress and produce intrinsic antinociception. A small number of clinical studies has examined the peripheral analgesic effects of opioids. Their results are equivocal so far. In view of the predominant role of the inflammatory process in the manifestation of peripheral opioid effects, the postoperative situation seems to be particularly worthwhile to study.

References

Oct 17, 1991·The New England Journal of Medicine·C SteinK Peter
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C SteinA Herz
Dec 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·L BarthóA Herz
Jan 1, 1989·Neuroscience·J D Levine, Y O Taiwo
Jan 1, 1988·Annual Review of Immunology·N E Sibinga, A Goldstein
Dec 1, 1987·British Journal of Clinical Pharmacology·R L HollandA Telekes
Jan 1, 1986·Annual Review of Pharmacology and Toxicology·V Höllt
Dec 1, 1986·Pain·Mark J Millan
Jun 1, 1988·Anaesthesia·J B DahlJ A Dahl
Feb 1, 1988·Journal of Neurocytology·R L PriceM J Katz
May 1, 1987·Anesthesia and Analgesia·K S MaysM Schnapp
May 1, 1985·Pain·C R ChapmanA E Reading
Mar 16, 1984·European Journal of Pharmacology·S H FerreiraG A Rae
Feb 1, 1983·Anesthesia and Analgesia·R BullinghamA Moore

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Citations

Sep 1, 1993·Der Schmerz·H W StriebelN Boerger
Jan 1, 1996·European Psychiatry : the Journal of the Association of European Psychiatrists·H HampelM Ackenheil

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