Abstract
To evaluate levels of oxidative stress in blood samples in patients with relapsing-remitting MS (RR-MS). Peripheral blood samples were collected from 24 RR-MS patients and 15 healthy controls. Levels of the following were measured: carbonylated proteins, 8-hydroxy-2'deoxyguanosine (8OHdG), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione-S-transferase (GST), myeloperoxidase (MPO), antioxidant gap, total antioxidant capacity (PAO), global oxidative stress (GOS), serum vascular cell adhesion molecule-1 (sVCAM-1) and serum inter-cellular adhesion molecule 1 (sICAM-1). Values for carbonylated proteins, 8OHdG, total glutathione, GSH, GSH/GSSG ratio, SOD, GRd and GOS were significantly higher in RR-MS patients than in healthy controls. By contrast, PAO, GSSG, GPx and GST were lower in RR-MS patients. Oxidative stress plays a major role in MS, and is observed prior to relapse.
References
Nov 1, 1983·Neurology·J F Kurtzke
Jan 1, 1984·The International Journal of Biochemistry·G PolidoroG Federici
Jun 1, 1997·Neurology·G GiovannoniE J Thompson
Nov 24, 1999·Neurology·A GrecoG Levi
Oct 31, 2002·Journal of Neuroscience Research·Vittorio CalabreseGiovanni Pennisi
Jun 10, 2003·Nutritional Neuroscience·Halit Tanju Besler, Selçuk Comoğlu
Feb 25, 2005·Journal of Neurology·Göksemin AcarEgemen Idiman
Aug 24, 2005·Antioxidants & Redox Signaling·Ralf Dringen
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Apr 18, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M KochJ De Keyser
Oct 3, 2009·Amino Acids·Danila Di GiuseppePaolo Di Simplicio
Mar 20, 2010·The Journal of Medical Investigation : JMI·Elzbieta MillerJózef Kedziora
Mar 23, 2010·Cell·Christopher K GlassFred H Gage
Apr 9, 2010·The International Journal of Neuroscience·Mojdeh GhabaeeFarzad Asadi
Jul 6, 2010·Biochimica Et Biophysica Acta·Jack van HorssenHelga E de Vries
Mar 15, 2011·Neurochemical Research·Elżbieta MillerMajsterek Ireneusz
Apr 23, 2011·Neuroscience·S LiY Zhang
May 4, 2011·Neuroscience·A CastegnaD C Hooper
May 6, 2011·Journal of Neurology·Anette S FjeldstadRussell S Richardson
May 17, 2011·Microvascular Research·Peter V Usatyuk, Viswanathan Natarajan
Jun 10, 2011·Brain : a Journal of Neurology·Lukas HaiderHans Lassmann
Citations
Jun 14, 2013·PloS One·Ada FioriniMarzia Perluigi
Oct 15, 2013·PloS One·Yixin HeZhengtao Wang
Dec 3, 2013·Journal of Neuroimmunology·Izabela Sadowska-BartoszGrzegorz Bartosz
Mar 4, 2014·European Journal of Pharmacology·Carmen BahamondeIsaac Túnez
Feb 24, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·A Suneetha, K Raja Rajeswari
Dec 19, 2015·Life Sciences·Solaleh EmamgholipourMohammad Ansari
Aug 21, 2013·Pharmacological Reports : PR·Inmaculada TassetIsaac Túnez
Dec 17, 2014·Molecular Neurobiology·Srdjan Ljubisavljevic
Oct 1, 2013·Nutritional Neuroscience·Mustafa NazirogluVedat Ali Yurekli
May 11, 2013·The International Journal of Neuroscience·Meisam SanoobarMahmood Reza Gohari
Apr 18, 2014·Journal of Immunology Research·Maira GironiRoberto Furlan
Apr 19, 2015·BMC Medicine·Gerwyn Morris, Michael Berk
Nov 26, 2013·Journal of the Neurological Sciences·Srdjan LjubisavljevicDusica Pavlovic
Jan 31, 2015·The Journal of Nutritional Biochemistry·Fabiano B CarvalhoCinthia M Andrade
Oct 11, 2014·Clinical Biochemistry·Livia PasqualiUbaldo Bonuccelli
Oct 12, 2014·Clinical Biochemistry·Martin KarlíkPeter Celec
Jun 14, 2016·Neurotoxicity Research·S LjubisavljevicD A Pavlovic
Jul 15, 2016·Biomarkers in Medicine·Richard IbitoyeAlastair Wilkins
Oct 9, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Begoña M EscribanoIsaac Túnez
Feb 18, 2017·International Journal of Molecular Sciences·Cecilia RajdaLászló Vécsei
May 4, 2017·Free Radical Research·Francisco J Medina-FernandezIsaac Tunez
Jun 2, 2017·Multiple Sclerosis : Clinical and Laboratory Research·In-Young ChoiSharon G Lynch
May 23, 2015·Metallomics : Integrated Biometal Science·Bárbara Rita CardosoDominic J Hare
May 21, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Andreia N CarvalhoJack Van Horssen
Apr 12, 2013·International Journal of Molecular Sciences·Sigrid G L FischerPeter G Scheffer
Jan 3, 2018·Molecular Neurobiology·Gerwyn MorrisBasant K Puri
Oct 18, 2018·Free Radical Research·Bożena AdamczykMonika Adamczyk-Sowa
Feb 8, 2019·Neurological Research·Şadiye GümüşyaylaÖzcan Erel
Apr 25, 2020·Brain Sciences·Giovanni SchepiciEmanuela Mazzon
Oct 1, 2013·Reviews in the Neurosciences·Francisco Javier Medina, Isaac Túnez
Jan 13, 2017·BioMed Research International·Natalia NiedzielaMariusz Gąsior
Oct 6, 2017·JCI Insight·Pavan BhargavaEllen M Mowry
Nov 7, 2019·Journal of Clinical Medicine·Rodica PadureanuAna-Maria Buga
Sep 10, 2020·Frontiers in Neurology·Eduardo AgüeraIsaac Túnez
Nov 16, 2017·Oxidative Medicine and Cellular Longevity·Bożena AdamczykMonika Adamczyk-Sowa
Mar 3, 2020·Frontiers in Neurology·Daniel A MontiAndrew B Newberg
Aug 11, 2020·Oxidative Medicine and Cellular Longevity·Andrés García-SánchezErnesto Germán Cardona-Muñoz
Aug 14, 2020·Autoimmune Diseases·Mohammad Javad TavassolifarMaryam Izad
Feb 26, 2019·Frontiers in Neuroscience·Mariacristina SiottoFabrizio Vernieri
Sep 29, 2020·Frontiers in Neuroscience·Shu-Yao ZhangYong Cheng
Oct 17, 2019·Nutrients·Cristina CondeIsaac Túnez
Dec 7, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Gönül VuralÖzcan Erel
Jan 19, 2019·Annals of Clinical and Translational Neurology·Pavan BhargavaPeter A Calabresi
Oct 10, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mahnaz TalebiSaeed Sadigh-Eteghad
Feb 16, 2021·Gene·Roya AmirinejadMehrdad Behmanesh
Jun 1, 2021·Frontiers in Immunology·Eduardo Duarte-SilvaChristina Alves Peixoto
Aug 12, 2021·Heliyon·Shiva ShahrampourAndrew B Newberg