Peripheral oxytocin injection modulates vomeronasal sensory activity and reduces pup-directed aggression in male mice.

Scientific Reports
Thiago S NakaharaFabio Papes

Abstract

Behaviors are shaped by hormones, which may act either by changing brain circuits or by modifying sensory detection of relevant cues. Pup-directed behaviors have been previously shown to change via action of hormones at the brain level. Here, we investigated hormonal control of pup-induced activity in the vomeronasal organ, an olfactory sensory structure involved in the detection of non-volatile chemosignals. Vomeronasal activity decreases as males switch from a pup-aggressive state to a non-aggressive parenting state, after they socially contact a female. RNA sequencing, qPCR, and in situ hybridization were used to identify expression, in the vomeronasal sensory epithelium, of candidate GPCR hormone receptors chosen by in silico analyses and educated guesses. After identifying that oxytocin and vasopressin receptors are expressed in the vomeronasal organ, we injected the corresponding hormones in mice and showed that oxytocin administration reduced both pup-induced vomeronasal activity and aggressive behavior. Conversely, injection of an oxytocin receptor antagonist in female-primed male animals, which normally exhibit reduced vomeronasal activity, significantly increased the number of active vomeronasal neurons. These data li...Continue Reading

References

Sep 1, 1990·Hormones and Behavior·M M McCarthy
Jan 1, 1988·Physiology & Behavior·J A Mennella, H Moltz
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M NovotnyJ Alberts
Jan 1, 1986·Physiology & Behavior·M M McCarthy, F S Vom Saal
Nov 1, 1981·Physiology & Behavior·B Svare, M Mann
Apr 13, 2000·Biochimica Et Biophysica Acta·S Spiegel, S Milstien
Jun 26, 2001·Brain Research. Brain Research Reviews·J L Goodson, A H Bass
Jun 14, 2003·Behavioral Neuroscience·Janet K Bester-Meredith, Catherine A Marler
Apr 29, 2004·Nature Neuroscience·Nathaniel Heintz
Sep 29, 2004·Nature Neuroscience·Larry J Young, Zuoxin Wang
Oct 7, 2004·Hormones and Behavior·Heather K Caldwell, H Elliott Albers
Dec 8, 2004·Current Opinion in Neurobiology·Eric B Keverne, James P Curley
Oct 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yuki TakayanagiKatsuhiko Nishimori
Dec 7, 2007·Progress in Neurobiology·Heather K CaldwellW Scott Young
Sep 24, 2008·Annual Review of Physiology·Steven D MungerFrank Zufall
Jul 9, 2009·Physiological Reviews·Roberto TirindelliAnna Menini
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·C Andrea Yao, John R Carlson
Feb 23, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kumi O KurodaMichael Numan
May 4, 2011·World Journal of Biological Chemistry·Kelley M ArgravesW Scott Argraves
Sep 23, 2011·Nature·Yoh IsogaiCatherine Dulac
May 23, 2012·Hormones and Behavior·Monica B DhakarHeather K Caldwell
Nov 28, 2012·Cell·Zachary A KnightJeffrey M Friedman
Dec 25, 2012·Neuron·Alison M BoydJeffry S Isaacson
Mar 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kashiko S TachikawaKumi O Kuroda
May 16, 2014·Nature·Zheng WuCatherine G Dulac
Sep 5, 2014·PLoS Genetics·Ximena Ibarra-SoriaDarren W Logan
Jan 3, 2015·Physiology & Behavior·Michael S SinclairNirupa Chaudhari
Sep 1, 2015·Frontiers in Neuroscience·Vinicius M A CarvalhoFabio Papes

❮ Previous
Next ❯

Citations

Mar 9, 2021·Frontiers in Cellular Neuroscience·Anne-Charlotte TrouilletPablo Chamero

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-Seq
PCR
dissection
in vitro transcription
acetylation

Software Mentioned

HTSeq
blastp
Ensembl
ImageJ
GraphPad Prism
STAR
Blast
R package
XLSTAT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
T Osada
Cellular and Molecular Life Sciences : CMLS
Alexandra C Brignall, Jean-François Cloutier
Izvestiia Akademii nauk. Seriia biologicheskaia
V I Gulimova, S V Savel'ev
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
A N ClancyE P Noble
© 2021 Meta ULC. All rights reserved