PMID: 3744468Sep 1, 1986

Peripheral pressor systems in hypertension caused by nucleus tractus solitarius lesions

Hypertension
A F Sved

Abstract

The roles of vasopressin, the sympathoadrenal system, and the renin-angiotensin system in the production of hypertension after bilateral destruction of the nucleus tractus solitarius (NTS) were examined in chloralose-anesthetized rats. Since the activity of the renin-angiotensin system is high in anesthetized rats, additional studies were performed in unanesthetized, freely moving rats to evaluate the role of the renin-angiotensin system in hypertension caused by NTS lesions. Hypertension produced by bilateral electrolytic NTS lesions in rats was accompanied by elevated plasma levels of vasopressin (approximately 7-fold), norepinephrine (greater than 10-fold), and epinephrine (greater than 10-fold), but not of plasma renin activity. These results suggest that this form of hypertension is due to increased sympathoadrenal activity and increased vasopressin release into plasma and that the renin-angiotensin system is not involved. In rats with NTS lesions, blockade of vasopressin or the sympathoadrenal system, but not the renin-angiotensin system, elicited an acute decrease in arterial pressure. However, blockade of either vasopressin or the autonomic nervous system before production of the lesions had no effect on the resulting h...Continue Reading

Citations

Jan 1, 1997·Clinical and Experimental Pharmacology & Physiology·A F SvedC K Kost
Nov 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ameya NayateW T Talman
Feb 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerA F Sved
Nov 13, 2018·Anesthesiology·Heberto Suarez-RocaWilliam Maixner
Aug 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A M SchreihoferA F Sved
Jan 14, 1999·The American Journal of Physiology·A M SchreihoferEdward M Stricker
Aug 23, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Phouangmala ScruggsNae J Dun
Dec 22, 1999·The American Journal of Physiology·C E Wood, H Tong
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerEdward M Stricker
Mar 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerA F Sved

Related Concepts

Adrenal Medulla
Hypertensive Disease
Medulla Oblongata
Pressoreceptors
August Rats
Renin-angiotensin System
Sympathetic Nervous System
Pitressin

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