Abstract
The roles of vasopressin, the sympathoadrenal system, and the renin-angiotensin system in the production of hypertension after bilateral destruction of the nucleus tractus solitarius (NTS) were examined in chloralose-anesthetized rats. Since the activity of the renin-angiotensin system is high in anesthetized rats, additional studies were performed in unanesthetized, freely moving rats to evaluate the role of the renin-angiotensin system in hypertension caused by NTS lesions. Hypertension produced by bilateral electrolytic NTS lesions in rats was accompanied by elevated plasma levels of vasopressin (approximately 7-fold), norepinephrine (greater than 10-fold), and epinephrine (greater than 10-fold), but not of plasma renin activity. These results suggest that this form of hypertension is due to increased sympathoadrenal activity and increased vasopressin release into plasma and that the renin-angiotensin system is not involved. In rats with NTS lesions, blockade of vasopressin or the sympathoadrenal system, but not the renin-angiotensin system, elicited an acute decrease in arterial pressure. However, blockade of either vasopressin or the autonomic nervous system before production of the lesions had no effect on the resulting h...Continue Reading
References
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·P ZandbergW De Jong
Sep 1, 1977·Life Sciences·J D Peuler, G A Johnson
Mar 1, 1985·Hypertension·A F SvedD J Reis
Oct 1, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·Y Gutman, F Benzakein
Aug 13, 1982·Science·W W BlessingD J Reis
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·M J WestJ Chalmers
Sep 1, 1981·Canadian Journal of Physiology and Pharmacology·C C Pang, K M Leighton
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Jul 1, 1980·Pharmacology, Biochemistry, and Behavior·B E LevinA C Sullivan
Citations
Jan 21, 1992·European Journal of Pharmacology·G BagdyK Szemeredi
May 1, 1989·Neuropharmacology·J C Sved, A F Sved
Jul 31, 1989·Neuroscience Letters·L LukovicD de Wied
Jan 1, 1997·Clinical and Experimental Pharmacology & Physiology·A F SvedC K Kost
Nov 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ameya NayateWilliam T Talman
Nov 29, 2001·Journal of Hypertension·I GavrasH Gavras
Mar 4, 2014·Neuroscience·F N BuijsR M Buijs
Feb 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerAlan F Sved
Nov 13, 2018·Anesthesiology·Heberto Suarez-RocaWilliam Maixner
Aug 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ann M SchreihoferAlan F Sved
Jan 14, 1999·The American Journal of Physiology·A M SchreihoferE M Stricker
Aug 23, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Phouangmala ScruggsNae J Dun
Dec 22, 1999·The American Journal of Physiology·C E Wood, H Tong
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S D StockerE M Stricker
Mar 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerAlan F Sved
Jan 14, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Diana Martinez, David D Kline