Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer's disease

Journal of Neuroinflammation
Luisa MinghettiA David Smith

Abstract

Oxidative stress is believed to be an early event and a key factor in Alzheimer's disease (AD) pathogenesis and progression. In spite of an intensive search for surrogate markers to monitor changes related to oxidative stress in the brain, there is as yet no consensus about which markers to use in clinical studies. The measurement of peripheral anti-oxidants is an alternative way of evaluating the involvement of oxidative stress in the course of the disease. Given the complexity of peripheral anti-oxidant defence, variations in the levels of individual anti-oxidant species may not fully reflect the overall capacity to fight oxidant conditions. We therefore chose to evaluate the total reductive capacity (herein defined as anti-oxidant capacity, AOC) in serum from control subjects and AD patients in order to study the association between peripheral anti-oxidant defence, cognitive impairment and patient survival. We measured the levels of AOC in serum samples from 26 cognitively normal controls and 25 AD patients (12 post-mortem confirmed) who completed the Cambridge Cognitive Assessment. Cognitive decline was assessed in a subgroup of 19 patients who underwent a second cognitive assessment 2 years after the initial visit. Serum A...Continue Reading

References

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Citations

Jan 21, 2010·Experimental Gerontology·Alessandra BerryFrancesca Cirulli
Nov 27, 2007·International Journal of Geriatric Psychiatry
Dec 4, 2020·Antioxidants & Redox Signaling·Jiao MengChang Chen

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Methods Mentioned

BETA
genotyping
ESRs

Software Mentioned

OPTIMA

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