Peripheral retinal function assessed with 30-Hz flicker seems to improve after treatment with Lucentis in patients with diabetic macular oedema

Documenta Ophthalmologica. Advances in Ophthalmology
Kristina HolmMonica Lövestam Adrian

Abstract

To evaluate the influence of ranibizumab on the multifocal electroretinogram (Mf-ERG), full-field electroretinogram (Ff-ERG) and optical coherence tomography (OCT) in diabetic eyes (n = 20) with macular oedema. In 20 eyes (20 diabetic subjects) with no or background diabetic retinopathy and macular oedema (age 65.7 ± 9.8 years, duration 16.5 ± 10.0 years), the change in ETDRS letters, Mf-ERG, Ff-ERG and OCT was analysed, at baseline, 4 weeks after the first injection, (just before the second injection), and 4 weeks after the last injection with ranibizumab. From baseline, mean BCVA improved from 64.0 ± 10.0 ETDRS letters to 75.0 ± 7.3 ETDRS letters (p = 0.005) 1 month after the last injection. Mean OCT thickness reduced after the first injection from 418 ± 117 to 311 ± 126 µm; (p = 0.001) and to 302 ± 74 µm after the third injection. Mf-ERG demonstrated in the innermost three rings a shorter implicit time after the first injection with p values of 0.002, 0.005 and 0.017, respectively. After the third injection, implicit time was prolonged to almost the original levels. Cone implicit time with 30-Hz flicker improved significantly between baseline (35.5 ± 3.6 ms) and final follow-up (34.6 ± 3.1 ms) (p = 0.04). Though the central ...Continue Reading

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Mar 31, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kristina HolmMonica Lövestam-Adrian
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Citations

Mar 24, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Barbara NowackaWojciech Lubiński
Apr 16, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·K B PedersenF Møller
Sep 6, 2018·Current Eye Research·Qingchen LiPeng Gao
Jul 18, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Arthur F ResendeL Jay Katz
Aug 2, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·YuDong FuDaBo Wang
Apr 13, 2021·Documenta Ophthalmologica. Advances in Ophthalmology·Kumiko KatoMineo Kondo

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