Peripheral somatic nerve function in relation to glucose tolerance in an elderly Caucasian population: the Hoorn study

Diabetic Medicine : a Journal of the British Diabetic Association
J N de NeelingL M Bouter

Abstract

Only sparse and contradictory data are available on peripheral somatic nerve function in relation to the total range of glucose tolerance. A random sample (n = 708) of people, stratified by age, sex, and glucose tolerance, from a Caucasian population aged 50 to 74 years was invited to undergo an examination including measures of large-fibre nerve function (ankle and knee reflexes, vibration sense, vibratory perception threshold (VPT) at the foot) and one measure of small-fibre function (thermal discrimination threshold (TDT) at the foot). A total of 267 subjects with a normal glucose tolerance (NGT), 167 with impaired glucose tolerance (IGT), 90 with newly diagnosed diabetes mellitus (NDM), and 73 with previously known diabetes (KDM) were included. KDM was associated with the highest prevalence of large-fibre nerve dysfunction. Within the range from NGT to NDM, most large-fibre function measures showed a decline with decreasing glucose tolerance. The TDT showed a decrease with an increase in fasting and post-load insulin levels (p < 0.05). We conclude that glucose intolerance is associated with impaired peripheral large-fibre nerve function, an association which seems to apply even in the non-diabetic range. Higher insulin leve...Continue Reading

Citations

Feb 24, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H E ResnickJ M Guralnik
Feb 12, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Dan ZieglerUNKNOWN KORA Study Group
Jun 29, 2004·Diabetes Care·Jay M SosenkoRonald B Goldberg
Feb 23, 2012·Diabetes Care·Peter J DyckWilliam J Litchy
Nov 1, 2008·Diabetes/metabolism Research and Reviews·Kazuhiro SugimotoMinoru Yasujima
Dec 6, 2005·Journal of Neurology·Alexander F J E VranckenNicolette C Notermans
Mar 3, 2007·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Nicholas J BevilacquaDavid G Armstrong
Aug 9, 2001·Muscle & Nerve·J R SingletonM B Bromberg
Dec 26, 2001·Muscle & Nerve·Helaine E ResnickAaron I Vinik
Jul 14, 2011·Nature Reviews. Endocrinology·Nikolaos PapanasDan Ziegler
Feb 8, 2008·Current Diabetes Reports·J Rob Singleton, A Gordon Smith
May 16, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sevki SahinKubilay Karsidag
May 9, 2012·Current Diabetes Reports·Nikolaos Papanas, Dan Ziegler
Nov 17, 2009·Orvosi hetilap·Zsuzsanna PutzGyörgy Jermendy
Mar 30, 2019·Diabetes Research and Clinical Practice·Muideen T OlaiyaWilliam C Knowler
May 20, 2021·BMJ Open Diabetes Research & Care·Varo KirthiUazman Alam

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