Peripheral T-cell lymphoma mimicking 5-aminosalicylate hypersensitivity in ulcerative colitis

Internal Medicine Journal
L M KongL Fisher

Abstract

5-aminosalicylates (5-ASA) remain an important strategy in the induction and maintenance of remission of inflammatory bowel diseases especially in ulcerative colitis. The prototypical drug of this class, sulfasalazine is generally well tolerated with severe hypersensitivity reactions and hepatotoxicity also described within the literature. When approaching a patient with an adverse reaction to 5-ASA, it can be difficult to differentiate clinically between a sulfa allergy versus a 5-ASA allergy versus a malignancy. We report on a case with initial signs and symptoms suggestive of a sulfa/5-ASA allergy that was subsequently found to be malignant in nature.

References

Jun 16, 1978·JAMA : the Journal of the American Medical Association·A A MihasR L Slaughter
Oct 1, 1978·The American Journal of Digestive Diseases·R S KannerM H Kalser
Nov 1, 1975·Clinical Pharmacology and Therapeutics·K M Das, M A Eastwood
Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·L C AnderssonH Wigzell
Jan 1, 1979·The British Journal of Surgery·A J BatchE R Reddy
May 1, 1989·Journal of Pediatric Gastroenterology and Nutrition·D L BoyerR A Friedman
May 1, 1986·Postgraduate Medicine·J D Haines
Oct 1, 1986·The American Journal of Medicine·G A Poland, K R Love
Jan 25, 2003·Anti-cancer Drugs·Peter W GoutMay C Robertson
Apr 22, 2006·Joint, Bone, Spine : Revue Du Rhumatisme·Ismail BejiaNaceur Bergaoui
Jul 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie M VoseInternational T-Cell Lymphoma Project
Jul 29, 2009·The American Journal of Medicine·Eric Macy, T Poon K-Y
Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Owen A O'ConnorSteven Horwitz
Apr 16, 2011·Blood·Francine M FossKensei Tobinai
Oct 21, 2014·Journal of Bioequivalence & Bioavailability·Chris StockmannCatherine Mt Sherwin

Citations

Feb 17, 2015·Gastroenterology Research and Practice·Cristiana PerrottaEmilio Clementi

Related Concepts

Ulcerative Colitis
Differential Diagnosis
Drug Allergy
Peripheral T-Cell Lymphoma
Novo-5 ASA
Malignant Neoplasms
Ulcerative Colitis
Hypersensitivity
Inflammatory Bowel Diseases
Literature

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