Peripheral T-cell lymphoma, not otherwise specified

Journal of Family Medicine and Primary Care
Kunal Kishor JhaNuwadatta Subedi

Abstract

The peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) belongs to a heterogeneous class of aggressive neoplasms. Although several morphologic subtypes of this tumor have been described, no particular genetic, immunological, or distinct clinical features define this disease. Patients can experience night sweats, fever, lymphadenopathy, weight loss, splenomegaly, and/or skin changes. Common laboratory tests reveal that patients have anemia, thrombocytosis, lymphocytosis, eosinophilia, hypergammaglobulinemia, or increased lactate dehydrogenase. In this case study, a patient presented with massive lymphadenopathy and right lower limb swelling, which he developed over 6 weeks. A tissue biopsy and supporting investigations confirmed the diagnosis of PTCL, NOS.

References

Oct 6, 2004·British Journal of Haematology·Ahmet Dogan, William G Morice
Dec 1, 2007·Hematological Oncology·Delvys Rodriguez-AbreuEmanuele Zucca
Jul 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie VoseUNKNOWN International T-Cell Lymphoma Project
Nov 21, 2008·Leukemia & Lymphoma·Abeer N AbouyabisChristopher R Flowers
Jan 29, 2011·Blood·Dennis D WeisenburgerUNKNOWN International Peripheral T-cell Lymphoma Project
Sep 7, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J S AbramsonA M Evens

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Methods Mentioned

BETA
biopsy
flow cytometry

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