Peripheral-T-cell lymphoma with hemophagocytic histiocytosis localised to the bone marrow associated with inappropriate secretion of antidiuretic hormone

Leukemia & Lymphoma
M CiaudoM Samama

Abstract

A patient with high fever, loss of weight and profound pancytopenia is reported. Peripheral T-cell lymphoma with hemophagocytosis was diagnosed. Bone marrow was the only localisation of the lymphoma. At presentation there were (i) a coagulopathy consistent with hemophagocytic histiocytosis (ii) the features of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). These different abnormalities disappeared after chemotherapy and reappeared during each of the 2 periods of disease progression. The patient died 6 months after diagnosis without ever achieving complete remission. As far as we are aware this is the first case report of T-cell lymphoma with hemophagocytic syndrome localised to the bone marrow and associated with SIADH.

References

Jun 1, 1988·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·A OkuboM Kikuchi
Feb 1, 1986·The American Journal of the Medical Sciences·R EliakimE Shinhar
Dec 5, 1974·The New England Journal of Medicine·A M Moses, M Miller
Mar 1, 1973·The American Journal of the Medical Sciences·P A Cassileth, B W Trotman

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Citations

May 15, 2012·Clinical Lymphoma, Myeloma & Leukemia·Bruno Bockorny, Constantin A Dasanu

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