Peripheral T-cell lymphoma with involvement of the expanded mantle zone.

Virchows Archiv : an International Journal of Pathology
Ida Münster IkonomouJan Delabie

Abstract

Peripheral T-cell lymphoma (PTCL) with a nodular architecture is rare. Recently, two variants have been described with infiltration of the B-cell follicle, one variant that localizes to the marginal zone with a so-called perifollicular growth pattern, and a variant that localizes to the germinal center. These lymphomas have a CD4+ phenotype and may express Bcl-6. We have studied five similar cases of PTCL with involvement of the B-cell follicle. However, our cases differ from the cases previously described by their predominant and frequently patchy involvement of the expanded mantle zone of the B-cell follicle at onset. Later biopsies in three of the cases show diffuse infiltration of the lymph node, without features of angioimmunoblastic TCL (AILT). All cases expressed Bcl-6 in addition to CD4. Cytogenetics was available in four of the cases but revealed no recurrent chromosomal aberrations or changes associated with other types of PTCL. No mutations of the BCL-6 gene were observed. Together, the cases seem to have an intermediately aggressive clinical behavior. Whether our cases are part of a spectrum of PTCLs that encompasses previously described variants with predominant marginal zone or germinal center infiltration or they...Continue Reading

References

Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jan 1, 1995·Cytogenetics and Cell Genetics·M HöglundF Mitelman
Jan 1, 1995·Cytogenetics and Cell Genetics·M HöglundN Mandahl
Mar 1, 1995·The American Journal of Surgical Pathology·W R MaconJ B Cousar
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·A MigliazzaR Dalla-Favera
Jun 18, 1998·The American Journal of Surgical Pathology·H J ReeD S Kim
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·L PasqualucciR Dalla-Favera
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·A L DentL M Staudt
Nov 11, 1999·European Journal of Immunology·S J GolbyJ Spencer
Jan 13, 2000·The American Journal of Surgical Pathology·T RüdigerH K Müller-Hermelink
Mar 4, 2000·Cancer Genetics and Cytogenetics·S LepretreC Bastard
Mar 7, 2000·The American Journal of Pathology·A RoersR Küppers
Feb 27, 2001·The American Journal of Surgical Pathology·L de LevalN L Harris
Dec 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·K KerlB Borisch
Jan 10, 2002·Blood·Ayoma AttygalleAhmet Dogan

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Citations

Jun 19, 2013·Best Practice & Research. Clinical Haematology·Ewa B Bajor-DattiloElaine S Jaffe
Sep 10, 2008·The American Journal of Surgical Pathology·Socorro María Rodríguez-PinillaMiguel A Piris
Dec 17, 2008·Hematology·Laurence de Leval, Philippe Gaulard
Aug 20, 2011·Seminars in Diagnostic Pathology·Philippe Gaulard, Laurence de Leval
Jan 26, 2011·Histopathology·Laurence de Leval, Philippe Gaulard
Dec 8, 2009·British Journal of Haematology·Laurence de LevalPhilippe Gaulard
Apr 29, 2015·Annals of Diagnostic Pathology·S J Ruiz, C V Cotta
Jan 22, 2015·Virchows Archiv : an International Journal of Pathology·Audrey DelasCamille Laurent
Jun 18, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mir AlikhanGirish Venkataraman
Oct 18, 2012·The American Journal of Surgical Pathology·Julien MorochPhilippe Gaulard
Nov 26, 2019·The American Journal of Surgical Pathology·Caoimhe EganElaine S Jaffe
Oct 16, 2019·Indian Journal of Pathology & Microbiology·Jienan KongZhenhua Lin

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