Peripheral T cell lymphomas in elderly patients: a retrospective analysis from the Hematology Association of South East Korea (HASEK)

Annals of Hematology
Jae-Cheol JoSung-Yong Oh

Abstract

Limited data are available on the clinical features and the outcomes of elderly patients with peripheral T cell lymphomas (PTCLs). We identified PTCL patients of age 60 years or older from the records of the Hematology Association of South East Korea between 2001 and 2014. The median age of the patients (70.4 % male) was 71 years (range 60-88 years). The majority (80.2 %) had stage III/IV disease, and 61.7 % of patients had Charlson comorbidity index (CCI) score 0. Out of 74 patients treated with chemotherapy, 62 were administered anthracycline-based combination chemotherapy (CHOP: 47 patients, CHOEP: 15 patients), and 12 received non-anthracycline-based combination chemotherapy (IMEP: 8 patients, and CVP: 4 patients). The overall response rate for the 74 patients treated with chemotherapy was 70.2 % (CR 37.8 % and PR 32.4 %). With a median follow-up of 23.8 (range 0.5-156) months, the estimated 5-year progression-free survival (PFS) and overall survival (OS) were 16.6 and 45.9 %, respectively. There were no significant differences in PFS and OS between patients treated with anthracycline-based and non-anthracycline-based combination chemotherapy. In the univariate analysis, increased age, elevated serum lactate dehydrogenase, ...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H GómezC Vallejos
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonUNKNOWN International Harmonization Project on Lymphoma
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martine Extermann, Arti Hurria
Dec 1, 2007·Hematological Oncology·Delvys Rodriguez-AbreuEmanuele Zucca
Dec 11, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C ThieblemontB Coiffier
Jul 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie VoseUNKNOWN International T-Cell Lymphoma Project
Oct 29, 2008·Hematology/oncology Clinics of North America·Julie M Vose
Jan 20, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J SuzumiyaUNKNOWN International Peripheral T-Cell Lymphoma Project
Nov 26, 2010·Expert Review of Hematology·Lodovico Balducci
Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Owen A O'ConnorSteven Horwitz
Jan 29, 2011·Blood·Dennis D WeisenburgerUNKNOWN International Peripheral T-cell Lymphoma Project
Mar 1, 2011·Blood·Richard L PiekarzSusan E Bates
Apr 16, 2011·Blood·Francine M FossKensei Tobinai
Apr 21, 2011·Leukemia & Lymphoma·Pier Luigi ZinzaniMichele Baccarani
Jun 2, 2014·European Journal of Internal Medicine·S DiemF Hitz

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Citations

Jul 3, 2021·Current Treatment Options in Oncology·Kitsada Wudhikarn, N Nora Bennani

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