Peripheral Tissue Chemokines: Homeostatic Control of Immune Surveillance T Cells.

Trends in Immunology
Michelle L McCullyB Moser

Abstract

Cellular immunity is governed by a complex network of migratory cues that enable appropriate immune cell responses in a timely and spatially controlled fashion. This review focuses on the chemokines and their receptors regulating the steady-state localisation of immune cells within healthy peripheral tissues. Steady-state immune cell traffic is not well understood but is thought to involve constitutive (homeostatic) chemokines. The recent discovery of tissue-resident memory T cells (TRM cells) illustrates our need for understanding how chemokines control immune cell mobilisation and/or retention. These studies will be critical to unravel novel pathways for preserving tissue function (aging) and preventing tissue disease (vaccination).

Citations

Apr 13, 2019·Immunological Reviews·Jillian M RichmondJohn E Harris
Oct 31, 2020·Frontiers in Immunology·Ariadni KouzeliBernhard Moser
Feb 9, 2021·World Journal of Clinical Cases·Min ChenHai-Tao Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds