PMID: 9439763May 1, 1997Paper

Peripheral-type benzodiazepine receptor ligands modulate human natural killer cell activity

International Journal of Immunopharmacology
H BesslerR Weizman

Abstract

Following our earlier work, we evaluated the in vitro effect of ligands active at the peripheral-type benzodiazepine receptors on human natural killer cell activity. Peripheral blood mononuclear cells were incubated with benzodiazepine receptor ligands. After 4 h we observed a nonspecific inhibition of natural killer cell activity induced by both peripheral (Ro5-4864 and PK 11195) and central (clonazepam) benzodiazepine receptor ligands; after 24 h, the suppressive activity was specific to peripheral and mixed (diazepam) ligands, and the central-type ligand had no effect. This significant, specific suppression of NK cell activity was completely reversed by the addition of human recombinant interleukin-2 or human leukocyte interferon. Our research provides additional information on the immunomodulatory effects of peripheral-type benzodiazepine ligands. Further studies are needed to clarify the underlying mechanism of natural killer cell inhibition and to determine the clinical implications of these findings.

References

Jan 1, 1979·Annual Review of Pharmacology and Toxicology·E Costa, A Guidotti
Feb 1, 1991·Current Opinion in Immunology·B Perussia
Jan 1, 1989·Advances in Immunology·G Trinchieri
Feb 1, 1985·Neuropeptides·M R RuffC B Pert
Aug 19, 1983·European Journal of Pharmacology·P MoingeonC Bohuon
Oct 1, 1984·The Journal of Experimental Medicine·G TrinchieriB Perussia

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Citations

Jan 26, 2010·Immunopharmacology and Immunotoxicology·R LazzariniJ Palermo-Neto
Dec 10, 1999·Immunopharmacology and Immunotoxicology·M S MorgulisJ Palermo-Neto
Oct 21, 2004·Anti-cancer Drugs·Didier Decaudin
Jun 19, 2021·The Journal of Trauma and Acute Care Surgery·Edward SkickiFrederick Rogers

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