Abstract
Patients with hypertrophic cardiomyopathy (HC) have coronary microvascular dysfunction, which is an independent predictor of adverse left ventricular remodeling, systolic dysfunction, and mortality in these patients. Whether these defects in vasomotor function are localized to the coronary arteries or whether systemic vasomotor dysfunction is present in patients with HC has not yet been adequately examined. The aim of this study was to test the hypothesis that patients with HC have altered peripheral vascular endothelial function. Subjects without coronary artery disease (CAD) and those with CAD served as negative and positive controls, respectively. Conduit artery endothelium-dependent vasomotion was assessed with ultrasound by measuring flow-mediated dilation of the brachial artery. Flow-mediated dilation was lower in patients with HC compared with those without CAD (p <0.05) but was similar in patients with CAD (p = NS). In conclusion, vasomotor dysfunction in HC is not restricted to the coronary vasculature. Patients with HC have impaired peripheral conduit vessel endothelial function, and the magnitude of impairment is similar to that seen in older patients with advanced CAD.
References
Jan 1, 1990·Heart and Vessels·T ImaizumiK Sueishi
Feb 1, 1985·Circulation·R O CannonS E Epstein
Nov 1, 1995·Journal of the American College of Cardiology·T J AndersonA C Yeung
Aug 1, 1994·Journal of the American College of Cardiology·D S CelermajerJ E Deanfield
Jan 1, 1993·Coronary Artery Disease·R PedrinelliP G Camici
Feb 1, 1996·Hypertension·K HasegawaS Sasayama
Feb 14, 1998·Circulation·R KramsP W Serruys
Jan 16, 1999·Japanese Circulation Journal·S KawanoI Yamaguchi
May 4, 1999·Angiology·P P DimitrowJ S Dubiel
Jan 24, 2003·The New England Journal of Medicine·Martin S MaronBarry J Maron
Sep 12, 2003·The New England Journal of Medicine·Franco CecchiPaolo G Camici
Mar 7, 2006·Journal of the American College of Cardiology·Iacopo OlivottoPaolo G Camici
Nov 8, 2006·Circulation·Martin S MaronBarry J Maron
Apr 25, 2007·Circulation·Joseph YeboahDavid M Herrington
Apr 25, 2007·Circulation·Steffen E PetersenHugh Watkins
Oct 10, 2007·Heart·P P DimitrowJ S Dubiel
Jan 9, 2008·International Journal of Cardiology·Marco GuazziRoss Arena
Sep 24, 2008·Circulation·Thierry Le TourneauBrigitte Jude
Jul 29, 2009·Circulation·Joseph YeboahDavid M Herrington
Citations
Aug 2, 2011·American Journal of Veterinary Research·Ian D JonesJonathan Elliott
Mar 1, 2012·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Ian D JonesJonathan Elliott
Aug 11, 2011·Echocardiography·Henriette GavallérAttila Nemes
Dec 28, 2010·The American Journal of Cardiology·Kevin S HeffernanUNKNOWN Vascular Function Study Group
Nov 14, 2015·Global Cardiology Science & Practice·Hala Mahfouz BadranMagdi Yacoub
Nov 19, 2013·Orvosi hetilap·Attila Nemes, Tamás Forster
Jun 18, 2011·American Journal of Hypertension·Kevin S Heffernan
Apr 22, 2011·American Journal of Hypertension·Francesco BartolomucciCarlo Palombo
Apr 1, 2017·Pediatric Cardiology·E FernlundP Liuba
Jun 3, 2017·Cardiology in Review·Kristina Selthofer-RelaticInes Drenjancevic
Mar 2, 2018·Antioxidants & Redox Signaling·Paul J M WijnkerJolanda van der Velden
Oct 4, 2019·European Heart Journal Cardiovascular Imaging·Monica RoşcaBogdan A Popescu
Mar 22, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Eva FernlundPetru Liuba