Peripheral venous lactate at admission is associated with in-hospital mortality, a prospective cohort study

Acta Anaesthesiologica Scandinavica
Charlotte BarfodKai Henrik Wiborg Lange

Abstract

The prognostic value of blood lactate as a predictor of adverse outcome in the acutely ill patient is unclear. The aim of this study was to investigate if a peripheral venous lactate measurement, taken at admission, is associated with in-hospital mortality in acutely ill patients with all diagnosis. Furthermore, we wanted to investigate if the test improves a triage model in terms of predicting in-hospital mortality. We retrieved a cohort of 2272 adult patients from a prospectively gathered acute admission database. We performed regression analysis to evaluate the association between the relevant covariates and the outcome measure: in-hospital mortality. Lactate as a continuous variable was a risk for in-hospital mortality with an odds ratio (OR) of 1.40 [95% confidence interval (CI) 1.25-1.57, P<0.0001]. OR for in-hospital mortality increased with increasing lactate levels from 2.97 (95% CI 1.55-5.72, P<0.001) for lactate between 2 mmol/l and 4 mmol/l, to 7.77 (95% CI 3.23-18.66, P<0.0001) for lactate>4 mmol/l. If the condition was non-compensated (i.e. pH<7.35), OR for in-hospital mortality increased to 19.99 (7.26-55.06, P<0.0001). Patient with a blood lactate at 4 mmol/l or more had a risk of in-hospital mortality equivalen...Continue Reading

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Citations

Apr 5, 2016·Critical Care Research and Practice·Maria Schollin-BorgJoakim Johansson
Feb 3, 2018·Case Reports in Transplantation·Shweta Yemul GolharStephen Guy
Apr 27, 2017·BMC Emergency Medicine·Tibor GondosGábor Halász
Aug 30, 2018·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Martin SchultzKasper Karmark Iversen
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