Peripherally-sourced myeloid antigen presenting cells increase with advanced aging.

Brain, Behavior, and Immunity
Pedram HonarpishehBhanu P Ganesh


Aging is associated with dysfunction of the gut microbiota-immune-brain axis, a major regulatory axis in both brain health and in central nervous system (CNS) diseases. Antigen presenting cells (APCs) play a major role in sensing changes in the gut microbiota and regulation of innate and adaptive immune responses. APCs have also been implicated in various chronic inflammatory conditions, including age-related neurodegenerative diseases. The increase in chronic low-level inflammation seen with aging has also been linked to behavioral decline. Despite their acknowledged importance along the gut microbiota-immune-brain axis, there is limited evidence on how APCs change with aging. In this study, we examined age-related changes in myeloid APCs in the gut, spleen, and brain as well as changes in the gut microbiota and behavioral phenotype in mice ranging in age from 2 months up to 32 months of both sexes. Our data show that the number of peripherally-sourced myeloid APCs significantly increases with advanced aging in the brain. In addition, our data showed that age-related changes in APCs are subset-specific in the gut and sexually dimorphic in the spleen. Our work highlights the importance of studying myeloid APCs in an age-, tissu...Continue Reading


Jan 5, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A TurturroR W Hart
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ralph Marvin Steinman, Michel C Nussenzweig
Mar 5, 2003·Annual Review of Immunology·Ralph M SteinmanMichel C Nussenzweig
May 14, 2005·Neurobiology of Aging·Matthew G FrankSteven F Maier
Jul 6, 2006·Applied and Environmental Microbiology·T Z DeSantisG L Andersen
Apr 5, 2007·Nature Protocols·Robert M J Deacon
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Jul 14, 2010·Ageing Research Reviews·Anshu Agrawal, Sudhir Gupta
Aug 10, 2010·Neurobiology of Aging·Ulrike W KaunznerKaren Bulloch
Jun 28, 2011·Bioinformatics·Robert C EdgarRob Knight
Aug 6, 2011·Trends in Immunology·Charlotte L ScottAllan McI Mowat
Dec 14, 2011·Expert Review of Clinical Immunology·Anshu AgrawalHarsh Agrawal
Nov 2, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Carol A Colton
Nov 20, 2012·Nature Immunology·Ansuman T SatpathyKenneth M Murphy
Jun 29, 2013·Current Opinion in Immunology·Christine Wong, Daniel R Goldstein
Dec 29, 2013·Experimental Gerontology·Sudhir Gupta
Jul 19, 2014·Nature Reviews. Immunology·Martin GuilliamsSimon Yona
Sep 6, 2014·Nature Reviews. Immunology·Wolfgang KastenmüllerRobert A Seder
Sep 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Zhenhong GuoJack L Strominger
Mar 31, 2015·Neurobiology of Aging·Rodney M RitzelLouise D McCullough
May 30, 2015·Journal of Neuroinflammation·Rodney M RitzelLouise D McCullough
Jul 3, 2015·Cold Spring Harbor Perspectives in Biology·Florent Ginhoux, Marco Prinz
Jan 7, 2016·Frontiers in Immunology·Paola BossùAntonio Ciaramella
Jul 28, 2016·Seminars in Immunopathology·Ari WaismanNir Yogev
Aug 23, 2016·Nature Reviews. Immunology·Sabra L Klein, Katie L Flanagan
Sep 21, 2016·Seminars in Immunopathology·Maisa C Takenaka, Francisco J Quintana
Nov 22, 2016·Journal of Neuroscience Research·Monica S SpychalaLouise D McCullough
Nov 29, 2016·Nature Reviews. Immunology·Tim WorbsReinhold Förster
Mar 23, 2017·Nature Immunology·Marco PrinzNora Hagemeyer
Apr 4, 2017·Immunology·Vivian M Turner, Neil A Mabbott
Apr 6, 2017·International Journal of Molecular Sciences·Edward C KoellhofferRodney M Ritzel
May 4, 2017·Nature Reviews. Immunology·Martin Guilliams, Charlotte L Scott
Sep 30, 2017·International Reviews of Immunology·Neema Negi, Bimal K Das
Dec 13, 2017·Archives of Medical Research·Carmen García-PeñaRobert P Friedland
Jan 26, 2018·Immunology Letters·Andreas RheinländerUrsula Bommhardt
Jan 30, 2018·Nature Reviews. Neurology·Melanie D SweeneyBerislav V Zlokovic

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