PMID: 9423860Jan 10, 1998Paper

Periplasmic superoxide dismutase in meningococcal pathogenicity

Infection and Immunity
K E WilksJ Simon Kroll

Abstract

Meningococcal sodC encodes periplasmic copper- and zinc-cofactored superoxide dismutase (Cu,Zn SOD) which catalyzes the conversion of the superoxide radical anion to hydrogen peroxide, preventing a sequence of reactions leading to production of toxic hydroxyl free radicals. From its periplasmic location, Cu,Zn SOD was inferred to acquire its substrate from outside the bacterial cell and was speculated to play a role in preserving meningococci from the action of microbicidal oxygen free radicals produced in the context of host defense. A sodC mutant was constructed by allelic exchange and was used to investigate the role of Cu,Zn SOD in pathogenicity. Wild-type and mutant meningococci grew at comparable rates and survived equally long in aerobic liquid culture. The mutant showed no increased sensitivity to paraquat, which generates superoxide within the cytosol, but was approximately 1,000-fold more sensitive to the toxicity of superoxide generated in solution by the xanthine/xanthine oxidase system. These data support a role for meningococcal Cu,Zn SOD in protection against exogenous superoxide. In experiments to translate this into a role in pathogenicity, wild-type and mutant organisms were used in an intraperitoneal mouse in...Continue Reading

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Citations

Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·J S KrollP R Langford
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·F C FangT Laessig
Feb 21, 2002·Infection and Immunity·Cliffton T H BongStanley M Spinola
Jun 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Kate L SeibAlastair G McEwan
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Dec 24, 2002·Infection and Immunity·Hsing-Ju TsengMichael P Jennings
Mar 17, 2001·Molecular Microbiology·C R JohnsonJ J McFadden
Apr 1, 2006·Molecular Microbiology·Hsing-Ju WuMichael P Jennings
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Feb 28, 2007·Infection and Immunity·Karen E Keith, Miguel A Valvano

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