Peripubertal environmental enrichment reverses the effects of maternal care on hippocampal development and glutamate receptor subunit expression

The European Journal of Neuroscience
Timothy W BredyMichael J Meaney

Abstract

Maternal care in the rat influences the development of cognitive function in the offspring through neural systems known to mediate activity-dependent synaptic plasticity. The offspring of mothers that exhibit increased levels of pup licking/grooming (high-LG mothers) show increased hippocampal N-methyl-D-aspartate (NMDA) subunit mRNA expression, enhanced synaptogenesis and improved hippocampal-dependent spatial learning in comparison with animals reared by low-LG mothers. The effects of reduced maternal care on cognitive function are reversed with peripubertal environmental enrichment; however, the neural mechanisms mediating this effect are not known. In these studies we exposed the offspring of high- and low-LG mothers to environmental enrichment from days 22 to 70 of life, and measured the expression of genes encoding for glutamate receptor subunits and synaptophysin expression as a measure of synaptic density. Environmental enrichment reversed the effects of maternal care on synaptic density and this effect was, in turn, associated with a reversal of the effect of maternal care on the NR2A and NR2B subunits of the NMDA receptor, as well as effects on (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) recep...Continue Reading

Citations

Nov 26, 2010·Psychopharmacology·Dawson W Hedges, Fu Lye Woon
Apr 4, 2009·Journal of Neural Transmission·Gregorio SegoviaFrancisco Mora
Jul 20, 2006·Journal of Abnormal Child Psychology·LeShawndra N PriceElizabeth B Robertson
Jun 14, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jeffrey M HalperinJocelyn T Curchack-Lichtin
Apr 18, 2006·Journal of Feline Medicine and Surgery·C A Tony BuffingtonRoger R Bolus
Oct 25, 2011·Development and Psychopathology·Barbara L Ganzel, Pamela A Morris
Jul 11, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amanda J LawPaul J Harrison
Aug 21, 2010·Nature Reviews. Neuroscience·Daniel A HackmanMichael J Meaney
Mar 10, 2009·Developmental Neuropsychology·Laura Hubbs-TaitBarbara J Stoecker
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ian C HellstromMichael J Meaney
Dec 5, 2009·Annual Review of Psychology·Tie-Yuan Zhang, Michael J Meaney
Apr 14, 2010·PLoS Biology·Alexander Kotrschal, Barbara Taborsky
Mar 10, 2011·PloS One·Patrick O McGowanMoshe Szyf
Aug 11, 2012·PloS One·Katarzyna JednorógFranck Ramus
Sep 4, 2013·Hormones and Behavior·Matthew R Green, Cheryl M McCormick
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rosemary C BagotMichael J Meaney
Jan 17, 2016·Developmental Cognitive Neuroscience·Roberta A Schriber, Amanda E Guyer
Aug 21, 2015·Developmental Psychobiology·Samuel A SakhaiDarlene D Francis
Oct 23, 2013·Epilepsy & Behavior : E&B·Jolien S van CampenMarian Joels
Dec 1, 2012·Behavioural Brain Research·Ana Laura VivinettoMaría Angélica Rivarola
Nov 6, 2012·Neuroscience·L Eiland, R D Romeo
Jun 18, 2011·Biological Psychiatry·Heather C Brenhouse, Susan L Andersen
Dec 24, 2015·Frontiers in Behavioral Neuroscience·Lauren E ChabyVictoria A Braithwaite
Jul 21, 2011·Neuroscience and Biobehavioral Reviews·Lars SchwabeMelly S Oitzl
Apr 5, 2011·Neuroscience and Biobehavioral Reviews·Annaliese K Beery, Darlene D Francis
Jul 24, 2010·Psychoneuroendocrinology·J P CurleyF A Champagne
May 12, 2009·Behavioural Brain Research·Laurence Coutellier, Hanno Würbel
Mar 19, 2009·Neurobiology of Learning and Memory·Rosemary C BagotMarian Joëls
Mar 3, 2009·Physiology & Behavior·Kathryn N ShepardMark E Wilson
Dec 1, 2015·Frontiers in Neuroendocrinology·James P Curley, Frances A Champagne
Jan 8, 2008·Neuroscience and Biobehavioral Reviews·Anandh Dhanushkodi, Ashok K Shetty
Nov 27, 2007·Brain Research Reviews·Francisco MoraAlberto Del Arco
Dec 10, 2015·Frontiers in Behavioral Neuroscience·Paola CaporaliLaura Petrosini
Jun 5, 2007·Neurobiology of Learning and Memory·Therese A KostenBen A Bahr

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.