Perirhinal cortex lesions impair context aversion learning

Learning & Memory
Dana J HowseDarlene M Skinner

Abstract

Rats with perirhinal cortex lesions were compared with sham controls on a conditional discrimination in which saccharin was paired with LiCl in context 1, but paired with saline in context 2. Perirhinal-lesioned rats were slightly slower to acquire the discrimination but reached control levels by the end of acquisition. Both groups showed transfer to familiar tap water, consuming less in context 1 than in context 2. Unlike sham rats, perirhinal rats failed to show an aversion to context 1 on a place choice test. These data provide neuroanatomical support for the postulated difference between Pavlovian conditioning and conditional learning.

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Citations

Jan 30, 2004·Learning & Memory·Ranier GutiérrezFederico Bermudez-Rattoni
Jun 25, 2016·NeuroImage·Cirong LiuTianzi Jiang
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jocelyne Bachevalier

Related Concepts

Avoidance Learning
Conditioning (Psychology)
Discrimination Learning
Rats, Long-Evans
Parahippocampal Gyrus

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