Perirhinal cortex lesions impair context aversion learning

Learning & Memory
Dana J HowseDarlene M Skinner


Rats with perirhinal cortex lesions were compared with sham controls on a conditional discrimination in which saccharin was paired with LiCl in context 1, but paired with saline in context 2. Perirhinal-lesioned rats were slightly slower to acquire the discrimination but reached control levels by the end of acquisition. Both groups showed transfer to familiar tap water, consuming less in context 1 than in context 2. Unlike sham rats, perirhinal rats failed to show an aversion to context 1 on a place choice test. These data provide neuroanatomical support for the postulated difference between Pavlovian conditioning and conditional learning.


Jan 1, 1992·Annual Review of Neuroscience·M Davis
Mar 1, 1991·Behavioral and Neural Biology·P R Hunt, J P Aggleton
Jan 1, 1990·Journal of Experimental Psychology. Animal Behavior Processes·G M MartinD van der Kooy
Apr 1, 1988·Behavioral Neuroscience·K A Stokes, P J Best
Apr 1, 1984·Behavioral Neuroscience·R T RossT W Berger
Jul 29, 1994·Behavioural Brain Research·K A Wiig, D K Bilkey
Dec 20, 1993·Behavioural Brain Research·J E LeDoux
Feb 1, 1994·Behavioral Neuroscience·D G Mumby, J P Pinel
Oct 1, 1993·Behavioral Neuroscience·M Bunsey, H Eichenbaum
Feb 1, 1993·Behavioral Neuroscience·R J McDonald, N M White
Apr 1, 1996·Current Opinion in Neurobiology·W A Suzuki
Feb 12, 1998·Behavioral Neuroscience·T Otto, D Garruto
May 20, 1998·Behavioral Neuroscience·P Liu, D K Bilkey
Nov 18, 2000·Experimental Brain Research·Timothy J BusseyJ P Aggleton
Nov 21, 2000·Behavioral Neuroscience·G TassoniC Bucherelli
Nov 21, 2000·Behavioral Neuroscience·David J BucciRebecca D Burwell
Feb 19, 2002·The European Journal of Neuroscience·Timothy J Bussey, Lisa M Saksida
Feb 19, 2002·The European Journal of Neuroscience·Timothy J BusseyElisabeth A Murray
Jun 7, 2002·Behavioral Neuroscience·David J BucciRebecca D Burwell


Jan 30, 2004·Learning & Memory·Ranier GutiérrezFederico Bermudez-Rattoni
Jun 25, 2016·NeuroImage·Cirong LiuTianzi Jiang
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jocelyne Bachevalier

Related Concepts

Avoidance Learning
Conditioning (Psychology)
Discrimination Learning
Rats, Long-Evans
Parahippocampal Gyrus

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.