Perispinal etanercept: potential as an Alzheimer therapeutic

Journal of Neuroinflammation
W Sue T Griffin

Abstract

Tumor necrosis factor-alpha (TNF) is one of a number of systemic and immunomodulating cytokines that generally act to promote acute-phase reactions but can drive degenerative changes when chronically elevated. Traditional focus on TNF has been directed at these inflammation-related functions. Of particular relevance to intersections between neuroinflammation and neurodegeneration is the ability of TNF to increase expression of interleukin-1 (IL-1), which in turn increases production of the precursors necessary for formation of amyloid plaques, neurofibrillary tangles, and Lewy bodies. More recent data have revealed that TNF, one of the few gliotransmitters, has strikingly acute effects on synaptic physiology. These complex influences on neural health suggest that manipulation of this cytokine might have important impacts on diseases characterized by glial activation, cytokine-mediated neuroinflammation, and synaptic dysfunction. Toward such manipulation in Alzheimer's disease, a six-month study was conducted with 15 probable-Alzheimer patients who were treated weekly with perispinal injection of Etanercept, an FDA-approved TNF inhibitor that is now widely used for treatment of rheumatoid arthritis and other systemic diseases as...Continue Reading

References

Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Mar 23, 2002·Science·Eric C BeattieRobert C Malenka
Nov 5, 2003·Journal of Neuroimmunology·Fiona M RossAlexej Verkhratsky
Dec 6, 2005·The European Journal of Neuroscience·Qinwen WangRoger Anwyl
Jan 3, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·John P Grant
Mar 21, 2006·Nature·David Stellwagen, Robert C Malenka
Jul 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Oleg ButovskyMichal Schwartz
Aug 26, 2006·Trends in Molecular Medicine·Gina G Turrigiano
Oct 28, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yona LevitesTodd E Golde
Sep 21, 2007·Journal of Neuropathology and Experimental Neurology·Robert E Mrak, W Sue T Griffin
Oct 25, 2007·Biochemical Society Transactions·M J RowanR Anwyl
Jan 11, 2008·Journal of Neuroinflammation·Edward L Tobinick, Hyman Gross
Jan 29, 2008·Current Alzheimer Research·Edward Tobinick

❮ Previous
Next ❯

Citations

Dec 24, 2009·The British Journal of Nutrition·Robert KrikorianJames A Joseph
Jan 2, 2013·Therapeutic Advances in Neurological Disorders·Konstantina G Yiannopoulou, Sokratis G Papageorgiou
Sep 11, 2009·Indian Journal of Psychiatry·Chittaranjan Andrade, Rajiv Radhakrishnan
Sep 4, 2013·The Journal of Endocrinology·Christian Hölscher
Jul 23, 2009·Brain Research Bulletin·Fabienne GiulianiFrançoise Schenk
Nov 26, 2008·Drug Discovery Today·Edward Tobinick
Dec 17, 2014·Geriatrics & Gerontology International·Sumit Gaur, Rupali Agnihotri
Dec 15, 2015·International Journal of Alzheimer's Disease·Mark E McCaulley, Kira A Grush
Apr 2, 2015·Archives of Toxicology·Olga Gorelenkova Miller, John J Mieyal
Aug 12, 2009·Neuroscience and Biobehavioral Reviews·Nicole DellaGioia, Jonas Hannestad
Jan 22, 2015·Acta Neuropathologica·Kirsten L Viola, William L Klein
Apr 28, 2016·CNS Drugs·Edward Lewis Tobinick
Jan 14, 2017·Expert Review of Neurotherapeutics·Ian A Clark
Jul 6, 2010·American Journal of Alzheimer's Disease and Other Dementias·Olapeju G AderinwaleShaker A Mousa
Jun 4, 2010·Expert Review of Neurotherapeutics·Edward Tobinick
Aug 24, 2019·Frontiers in Neuroscience·Minna Yli-KarjanmaaKate Lykke Lambertsen
Apr 27, 2021·British Journal of Pharmacology·Christian Hölscher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.

Related Papers

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Krishnan Sriram, James P O'Callaghan
© 2021 Meta ULC. All rights reserved