Perisynaptic schwann cells - The multitasking cells at the developing neuromuscular junctions.

Seminars in Cell & Developmental Biology
Paloma Alvarez-SuarezTomasz J Prószyński

Abstract

Neuromuscular junctions (NMJs) are specialized synapses in the peripheral nervous system that allow the transmission of neuronal impulses to skeletal muscles for their contraction. Due to its size and accessibility, the NMJ is a commonly used model for studying basic principles of synapse organization and function. Similar to synapses in the central nervous system, NMJs are composed of presynaptic axonal terminals, the postsynaptic machinery formed at the membrane of the muscle fibers, and the synapse-associated glial cells. The special glial cells at the NMJs are called terminal Schwann cells or perisynaptic Schwann cells (PSCs). Decades of studies on the NMJ, as well as the most recent discoveries, have revealed multiple functions for PSCs at different stages of synaptic formation, maintenance, and disassembly. This review summarizes major observations in the field.

Citations

Aug 25, 2020·Nano Research·Qiang ZhangDong Han
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Valentin Milichko, Vyacheslav Dyachuk
Dec 19, 2020·Biological Reviews of the Cambridge Philosophical Society·Diego ZeladaJuan P Henríquez
Mar 5, 2021·JCI Insight·Daisy ProiettiLuca Madaro
May 13, 2021·Brain Communications·Abrar AlhindiThomas H Gillingwater
Jul 11, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Stefano C Previtali
Apr 6, 2021·Aging and Disease·Sandra Fuertes-Alvarez, Ander Izeta

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