Peritoneal cancer index as a predictor of survival in advanced stage serous epithelial ovarian cancer: a prospective study

Journal of Gynecologic Oncology
Alaa A ElzarkaaAmr A Soliman

Abstract

A numerical score, the peritoneal cancer index (PCI), was developed to reflect the extent of tumor growth in gastric and colorectal cancers and to tailor treatment. This study aimed to examine the value of the PCI score in advanced epithelial ovarian cancer (EOC) regarding completeness of surgical cytoreduction and survival. This was a prospective observational cohort study. Patients with primary serous EOC at International Federation of Gynecology and Obstetrics (FIGO) stages IIIB or higher were included. Patients with FIGO stage IVB as well as those assigned to receive neoadjuvant treatment were excluded from the study. The PCI was obtained and registered intraoperatively. In the study period we recruited 96 patients with serous EOC stage IIIB-IVA. A PCI score cut-off value of 13 was calculated using a receiver operator characteristic (ROC) curve, above which worse survival is expected (area under the curve [AUC]=0.641; 95% confidence interval [CI]=0.517-0.765; sensitivity and specificity 80.6%, 45.0%, respectively; p=0.050). A multivariate analysis determined that suboptimal surgical cytoreduction was the only independent predictive factor for recurrence (odds ratio [OR]=7.548; 95% CI=1.473-38.675; p=0.015). A multivariate a...Continue Reading

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Citations

Nov 21, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mustafa Zelal MuallemAsya Parashkevova
Nov 28, 2018·Journal of Gynecologic Oncology·Wonkyo ShinMyong Cheol Lim
May 31, 2020·Annals of Surgical Oncology·Björg JónsdóttirKarin Stålberg
Aug 9, 2020·International Journal of Nanomedicine·Barbara BortotStefania Biffi
Jan 9, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Liang ZhaoHaojun Chen
Apr 6, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M P EngbersenW J Van Driel
Jun 14, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Feiling FengXiaoqing Jiang

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Methods Mentioned

BETA
surgical resections
hysterectomy

Software Mentioned

Excel
SPSS

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