Peritoneal Carcinomatosis Targeting with Tumor Homing Peptides

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Lorena Simón-GraciaTambet Teesalu

Abstract

Over recent decades multiple therapeutic approaches have been explored for improved management of peritoneally disseminated malignancies-a grim condition known as peritoneal carcinomatosis (PC). Intraperitoneal (IP) administration can be used to achieve elevated local concentration and extended half-life of the drugs in the peritoneal cavity to improve their anticancer efficacy. However, IP-administered chemotherapeutics have a short residence time in the IP space, and are not tumor selective. An increasing body of work suggests that functionalization of drugs and nanoparticles with targeting peptides increases their peritoneal retention and provides a robust and specific tumor binding and penetration that translates into improved therapeutic response. Here we review the progress in affinity targeting of intraperitoneal anticancer compounds, imaging agents and nanoparticles with tumor-homing peptides. We review classes of tumor-homing peptides relevant for PC targeting, payloads for peptide-guided precision delivery, applications for targeted compounds, and the effects of nanoformulation of drugs and imaging agents on affinity-based tumor delivery.

References

Feb 28, 1986·Cell·E Ruoslahti, M D Pierschbacher
Jan 1, 1985·The American Journal of Physiology·M F FlessnerR L Dedrick
Aug 1, 1995·Gynecologic Oncology·S A CannistraJ DiCarlo
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S BennisJ Robert
Mar 28, 1996·Nature·R Pasqualini, E Ruoslahti
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Jun 17, 1998·Clinical & Experimental Metastasis·T MatsuokaM Sowa
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kimmo PorkkaErkki Ruoslahti
Jun 8, 2002·Nature Medicine·Pirjo LaakkonenErkki Ruoslahti
Sep 28, 2002·The Journal of Biological Chemistry·Mitchell KoolpeElena B Pasquale
Jan 10, 2003·Journal of Liposome Research·David SadavaSusan E Kane
Mar 15, 2003·Nature Reviews. Cancer·Erkki Ruoslahti
Nov 26, 2003·The Journal of Cell Biology·Sven ChristianErkki Ruoslahti
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Jun 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Pirjo LaakkonenErkki Ruoslahti
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Premal H ThakerAnil K Sood
Aug 3, 2005·Gynecologic Oncology·Liping HanZhenhe Suo
Sep 21, 2006·Cancer Science·Noriyuki AkitaShinichi Miyagawa
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Ingrid DijkgraafOtto C Boerman
Mar 23, 2007·Pharmaceutical Research·Xiaomin FanCatherine M Woods
Jul 27, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A PovedaA González Martín
Feb 22, 2008·Molecular Biology of the Cell·Srujana CherukuriMichael Bustin
Jul 10, 2008·Journal of the American Chemical Society·Kenneth E ScarberryZ John Zhang
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tambet TeesaluErkki Ruoslahti
Dec 8, 2009·Cancer Cell·Kazuki N SugaharaErkki Ruoslahti
Dec 9, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Kenneth E ScarberryJohn F McDonald
Mar 4, 2010·Pharmaceutical Research·Gaurav Bajaj, Yoon Yeo
Mar 17, 2010·The Journal of Cell Biology·Erkki RuoslahtiMichael J Sailor
Nov 11, 2010·Future Oncology·Ze LuJessie L-S Au
May 5, 2011·International Journal of Molecular Sciences·Miranda P WeenCarmela Ricciardelli
Jan 11, 2012·Methods in Enzymology·Tambet TeesaluErkki Ruoslahti
Mar 1, 2012·Cancer Investigation·Björn L D M BrücherAviram Nissan
Aug 25, 2012·Future Medicinal Chemistry·Fernando Albericio, Hendrik G Kruger
Nov 1, 2012·World Journal of Gastroenterology : WJG·Yvonne L B KlaverIgnace H J T de Hingh
Dec 19, 2012·Cancer Research·Renwei ChenErkki Ruoslahti
Mar 7, 2013·Journal of Structural Biology·David ZanuyNurit Haspel
Aug 30, 2013·Frontiers in Oncology·Tambet TeesaluErkki Ruoslahti

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Citations

Feb 6, 2019·International Journal of Molecular Sciences·Stephan Niland, Johannes A Eble
Jan 6, 2019·Abdominal Radiology·David J BartlettShannon P Sheedy
Feb 6, 2021·International Journal of Pharmaceutics·Nicola d'AvanzoHélder A Santos
Apr 29, 2021·Angewandte Chemie·Lorena Simón-GraciaTambet Teesalu

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