Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: retrospective analysis of 523 patients from a multicentric French study

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Dominique EliasOlivier Glehen

Abstract

PURPOSE Peritoneal carcinomatosis (PC) from colorectal cancer traditionally is considered a terminal condition. Approaches that combine cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) have been developed recently. The purpose of this study was to assess early and long-term survival in patients treated with that strategy. PATIENTS AND METHODS A retrospective-cohort, multicentric study from French-speaking countries was performed. All consecutive patients with PC from colorectal cancer who were treated with CRS and PIC (with or without hyperthermia) were included. Patients with PC of appendiceal origin were excluded. Results The study included 523 patients from 23 centers in four French-speaking countries who underwent operation between 1990 and 2007. The median follow-up was 45 months. Mortality and grades 3 to 4 morbidity at 30 days were 3% and 31%, respectively. Overall median survival was 30.1 months. Five-year overall survival was 27%, and five-year disease-free survival was 10%. Complete CRS was performed in 84% of the patients, and median survival was 33 months. Positive independent prognostic factors identified in the multivariate analysis were complete CRS, PC that was limited in extent, ...Continue Reading

References

Jan 1, 1996·Cancer Treatment and Research·P Jacquet, P H Sugarbaker
Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·R C RietbroekC H Veenhof
Nov 14, 1997·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J V HettingaH H Kampinga
Jun 13, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P J van de VaartA C Begg
Nov 26, 2002·The British Journal of Surgery·D G JayneF Seow-Choen
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O GlehenP Rat
Apr 14, 2005·Annals of Surgical Oncology·Vic J VerwaalFrans A N Zoetmulder
Nov 1, 2006·Gastroentérologie Clinique Et Biologique·Dominique EliasMichel Ducreux
Jul 17, 2007·The British Journal of Surgery·R M SmeenkF A N Zoetmulder
Jun 25, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karl Y BilimoriaClifford Y Ko
Dec 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominique EliasJulia Bonastre

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Citations

Sep 21, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Paul H Sugarbaker
Nov 8, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C CaoUNKNOWN Peritoneal Surface Malignancy Group
Jul 27, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D HompesA D'Hoore
Sep 27, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J SchmollA Cervantes
Jul 27, 2011·Therapeutic Advances in Medical Oncology·Alexander SteinDirk Arnold
Dec 21, 2011·World Journal of Surgical Oncology·Timothy J Cooksley, Philip Haji-Michael
Jul 27, 2010·The Oncologist·Thomas Winder, Heinz-Josef Lenz
Oct 20, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Vincent BoudousqJean-Pierre Pouget
Apr 21, 2011·Current Oncology·F MohamedP Sugarbaker
Mar 20, 2010·World Journal of Gastroenterology : WJG·Bernardino RamponeGiuseppe Confuorto
Nov 14, 2013·World Journal of Gastroenterology : WJG·Federico CoccoliniFausto Catena
Jul 21, 2012·World Journal of Gastrointestinal Surgery·Ioannis T KonstantinidisEvan S Ong
Apr 25, 2014·Gastroenterology Report·Bhavith RemalayamRamachandran Thazhath Mavali
Apr 9, 2013·Future Oncology·Diane GoéréDominique Elias
Nov 8, 2013·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Charles HonoréDominique Elias
Dec 15, 2012·International Journal of Clinical Oncology·Hirotoshi KobayashiKenichi Sugihara
Nov 20, 2013·Langenbeck's Archives of Surgery·Yakup KuluAlexis Ulrich
Jun 7, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F LosaE Aranda
Feb 7, 2014·Annals of Surgical Oncology·Dominique EliasMichel Ducreux
Mar 1, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Parissa TabrizianDaniel M Labow
Aug 12, 2014·Indian Journal of Cancer·N DharmadhikariP Jagannath
Aug 26, 2014·Gynécologie, obstétrique & fertilité·D QuarantaJ-L Bernard
Jan 1, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B H M WilliamsD L Morris
Nov 20, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M ValleA Garofalo
Jun 12, 2014·International Journal of Colorectal Disease·Carlo VallicelliGiorgio M Verdecchia
May 2, 2014·BioMed Research International·Paul H Sugarbaker

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