Peritoneal dialysis as therapeutic option in heart failure patients

ESC Heart Failure
Leonie GrossekettlerV Schwenger

Abstract

Each episode of acute decompensated heart failure (HF) incrementally adds to mortality. Peritoneal dialysis (PD) offers an alternative therapeutic option in refractory HF and reduces the incidence of decompensation episodes. The objective of this study was to determine the efficacy of PD, in terms of functional status, surrogate endpoints, rate of hospitalizations, and mortality. This study is based on the registry of the German Society of Nephrology, involving 159 patients receiving PD treatment due to refractory HF between January 2010 and December 2014. Body weight was reduced by PD (82.2 ± 14.9 to 78.4 ± 14.8 kg, P < 0.001), and significant improvements in New York Heart Association functional class (3.38 ± 0.55 to 2.85 ± 0.49, P < 0.001) were found already after 3 months. Left ventricular ejection fraction did not change (31.5 ± 13.8 to 34.0 ± 15.7%, P = 0.175). C-reactive protein improved with PD treatment (33.7 ± 52.6 to 17.1 ± 26.3 mg/L, P = 0.004). Blood urea nitrogen/creatinine ratio decreased significantly (148.7 ± 68.3 to 106.7 ± 44.8 mg/dL, P < 0.001). Hospitalization rates decreased significantly (total number 2.86 ± 1.88 to 1.90 ± 1.78, P = 0.001, and 39.2 ± 30.7 to 27.1 ± 25.2 days, P = 0.004). One year mortalit...Continue Reading

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Citations

Dec 14, 2019·ESC Heart Failure·Vicente PerniasJulio Núñez
Apr 14, 2020·Seminars in Dialysis·Bethany RoehmDaniel E Weiner
Apr 17, 2020·Circulation. Heart Failure·Hannah RosenblumDaniel Burkhoff
Sep 2, 2020·Journal of Nephrology·Giacomo DeferrariEdoardo La Porta
Jun 28, 2019·Expert Review of Cardiovascular Therapy·Amir Kazory, Joanne M Bargman
May 16, 2020·BMC Nephrology·Leonie GrossekettlerAndrew Remppis
Feb 12, 2020·Turkish Journal of Medical Sciences·Nihan Tekkarişmaz, Dilek Torun
Oct 24, 2020·Seminars in Dialysis·Eray ErogluBengt Lindholm
Oct 30, 2020·ESC Heart Failure·Markus S AnkerStephan von Haehling
Jul 23, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Rafael de la EspriellaJulio Núñez
Oct 5, 2021·Der Internist·Vedat SchwengerAndrew Remppis
Dec 26, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Dilek Aslan KutsalBarış Güngör

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