Peritoneal dialysis solutions reverse the hemodynamic effects of nitric oxide synthesis inhibitors

Kidney International
R WhiteJ Work

Abstract

Nitric oxide (NO) synthesis is inhibited by a variety of L-arginine analogs including NG-nitro-L-arginine methyl ester (L-NAME) and NG NG-dimethylarginine (ADMA). ADMA is present in elevated concentrations in renal failure and potentially could alter microcirculatory hemodynamics during peritoneal dialysis (PD). This investigation utilized the techniques of intravital microscopy to quantitate the mesenteric arteriolar hemodynamic effects of PD solutions during NO synthesis inhibition. L-NAME (100 microns) produced maximum arteriolar vasoconstriction to 74% of baseline diameter (19.9 +/- 2.2 vs. 26.9 +/- 1.4 microns, P < 0.001, N = 10) and ADMA (100 microns) to 68% (20.5 +/- 2.5 vs. 30.1 +/- 2.0 microns, P < 0.01, N = 6). L-NAME decreased red blood cell velocity to 44% of baseline velocity (3.8 +/- 0.8 vs. 8.5 +/- 1.1 mm/second, P < 0.001) and ADMA to 52% (5.1 +/- 1.1 vs. 9.8 +/- 0.9 mm/second, P < 0.01, N = 6). Despite NO synthesis inhibition, standard PD solutions reversed these hemodynamic effects with both 1.5% and 4.25% Dianeal (Baxter) rapidly reversing the vasoconstriction and restoring blood flow back to baseline values. When Dianeal and L-NAME were simultaneously superfused, no L-NAME induced vasoconstriction occurred a...Continue Reading

References

Jun 1, 1979·Kidney International·F N MillerA J Ghods
Sep 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·F N MillerJ Rubin
Jan 1, 1992·Journal of Cardiovascular Pharmacology·P VallanceS Moncada
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
May 1, 1990·Hypertension·S M GardinerS Moncada
Sep 1, 1981·Kidney International·F N MillerD B Andersen
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Mar 1, 1994·Kidney International·R J MacAllisterP Vallance
Oct 1, 1994·Journal of the American Society of Nephrology : JASN·R MacAllister, P Vallance
Jul 1, 1993·Circulation Research·I KuroseD N Granger

❮ Previous
Next ❯

Citations

Aug 11, 2000·Kidney International. Supplement·A DhondtN Lameire
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jan T Kielstein, Carmine Zoccali
Sep 1, 2015·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Shigehisa AokiShuji Toda
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·R Vanholder, R De Smet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.